Abstract
Adult mice injected with a sheep red blood cell hemolysate supernatant fraction were found to have a severely reduced responsiveness to subsequent immunization with sheep red blood cells. The induced unresponsiveness was found to be specific, as tested by reciprocal experiments involving horse and sheep erythrocyte preparations. The tolerogenic material did not appear to be immunogenic.
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Selected References
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- Aisenberg A. C. Studies on cyclophosphamide-induced tolerance to sheep erythrocytes. J Exp Med. 1967 May 1;125(5):833–845. doi: 10.1084/jem.125.5.833. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
- DRESSER D. W. Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen. Immunology. 1962 May;5:378–388. [PMC free article] [PubMed] [Google Scholar]
- FRIEDMAN H. FAILURE OF SPLEEN CELLS FROM IMMUNOLOGICALLY TOLERANT MICE TO FORM ANTIBODY PLAQUES TO SHEEP ERYTHROCYTES IN AGAR GEL. Nature. 1965 Jan 30;205:508–509. doi: 10.1038/205508b0. [DOI] [PubMed] [Google Scholar]
- Fetherstonhaugh P. The immunogenicity and tolerance-inducing ability of soluble extracts of sheep red blood cell membranes. Int Arch Allergy Appl Immunol. 1970;39(2-3):310–322. doi: 10.1159/000230357. [DOI] [PubMed] [Google Scholar]
- Frisch A. W., Davies G. H. Inhibition of hemagglutin synthesis by cytoxan: specificity and drug-induced "tolerance". J Lab Clin Med. 1966 Jul;68(1):103–112. [PubMed] [Google Scholar]
- Leskowitz S. Tolerance. Annu Rev Microbiol. 1967;21:157–180. doi: 10.1146/annurev.mi.21.100167.001105. [DOI] [PubMed] [Google Scholar]
- Playfair J. H. Specific tolerance to sheep erythrocytes in mouse bone marrow cells. Nature. 1969 May 31;222(5196):882–883. doi: 10.1038/222882a0. [DOI] [PubMed] [Google Scholar]
- Weigle W. O. Recent observations and concepts in immunological unresponsiveness and autoimmunity. Clin Exp Immunol. 1971 Oct;9(4):437–447. [PMC free article] [PubMed] [Google Scholar]