Abstract
Comparable numbers of types 1, 2, 3, and 4 gonococci were placed on the intact chorioallantoic membrane of 236, 10-day old chick embryos. Types 1 and 2 organisms produced infection and could be cultured from chorioallantoic fluid 2 days later significantly more often (69%) than types 3 and 4 organisms (12%, P < 0.001). This confirms in an animal model the same correlation between colony types and infectivity observed in human volunteers and suggests that types 1 and 2 gonococci possess a fundamental virulence characteristic which is absent from types 3 and 4 organisms. Gonococcal infection of the chick embryo chorioallantoic cavity remains a useful model somewhat analogous to localized gonococcal infection in man.
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Selected References
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- Bang F. EXPERIMENTAL GONOCOCCUS INFECTION OF THE CHICK EMBRYO. J Exp Med. 1941 Sep 30;74(4):387–396. doi: 10.1084/jem.74.4.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barr J., Danielsson D. Septic gonococcal dermatitis. Br Med J. 1971 Feb 27;1(5747):482–485. doi: 10.1136/bmj.1.5747.482. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Buddingh G. J., Polk A. D. A STUDY OF PASSIVE IMMUNITY TO MENINGOCOCCUS INFECTION IN THE CHICK EMBRYO. J Exp Med. 1939 Oct 31;70(5):511–520. doi: 10.1084/jem.70.5.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GREAVES R. I. Preservation of living cells by freeze-drying. Ann N Y Acad Sci. 1960 Apr 13;85:723–728. doi: 10.1111/j.1749-6632.1960.tb49992.x. [DOI] [PubMed] [Google Scholar]
- Holmes K. K., Weisner P. J., Pedersen A. H. The gonococcal arthritis-dermatitis syndrome. Ann Intern Med. 1971 Sep;75(3):470–471. doi: 10.7326/0003-4819-75-3-470. [DOI] [PubMed] [Google Scholar]
- Jephcott A. E., Reyn A., Birch-Andersen A. Neisseria gonorrhoeae 3. Demonstration of presumed appendages to cells from different colony types. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;79(3):437–439. doi: 10.1111/j.1699-0463.1971.tb00086.x. [DOI] [PubMed] [Google Scholar]
- KELLOGG D. S., Jr, PEACOCK W. L., Jr, DEACON W. E., BROWN L., PIRKLE D. I. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION. J Bacteriol. 1963 Jun;85:1274–1279. doi: 10.1128/jb.85.6.1274-1279.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kellogg D. S., Jr, Cohen I. R., Norins L. C., Schroeter A. L., Reising G. Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 months in vitro. J Bacteriol. 1968 Sep;96(3):596–605. doi: 10.1128/jb.96.3.596-605.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swanson J., Kraus S. J., Gotschlich E. C. Studies on gonococcus infection. I. Pili and zones of adhesion: their relation to gonococcal growth patterns. J Exp Med. 1971 Oct 1;134(4):886–906. doi: 10.1084/jem.134.4.886. [DOI] [PMC free article] [PubMed] [Google Scholar]
- THAYER J. D., MARTIN J. E., Jr A SELECTIVE MEDIUM FOR THE CULTIVATION OF N. GONORRHOEAE AND N. MENINGITIDIS. Public Health Rep. 1964 Jan;79:49–57. [PMC free article] [PubMed] [Google Scholar]