Abstract
β2-microglobulin was detected on the cell surface and in the medium of human lymphoid cells established in long-term culture. The secretion of β2-microglobulin was relatively uniform when different cell lines were compared, whereas IgG production varied widely. κ- and µ-membrane antigens were modulated by specific antibody; β2-microglobulin was not modulated. Anti-κ and anti-µ antisera had no effect on the expression of membrane β2-microglobulin, nor had anti-β2-microglobulin antiserum any effect on the expression of κ- and µ-membrane antigens.
Full Text
The Full Text of this article is available as a PDF (376.2 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bernier G. M., Fanger M. W. Synthesis of 2 -microglobulin by stimulated lymphocytes. J Immunol. 1972 Aug;109(2):407–409. [PubMed] [Google Scholar]
- Cejka J., Poulik M. D. Isolation of an 2 -globulin characteristic of tubular proteinuria. Arch Biochem Biophys. 1971 Jun;144(2):775–777. doi: 10.1016/0003-9861(71)90387-0. [DOI] [PubMed] [Google Scholar]
- Coombs R. R., Gurner B. W., Janeway C. A., Jr, Wilson A. B., Gell P. G., Kelus A. S. Immunoglobulin determinants on the lymphocytes of normal rabbits. I. Demonstration by the mixed antiglobulin reaction of determinants recognized by anti-gamma, anti-mu, anti-Fab and anti-allotype sera, anti-As4 and anti-As6. Immunology. 1970 Mar;18(3):417–429. [PMC free article] [PubMed] [Google Scholar]
- Hütteroth T. H., Litwin S. D., Cleve H. Cultured lymphoid cell lines from normal subjects: membrane associated immunoglobulins studied by the mixed antiglobulin reaction. Cell Immunol. 1972 Nov;5(3):446–458. doi: 10.1016/0008-8749(72)90071-8. [DOI] [PubMed] [Google Scholar]
- Peterson P. A., Cunningham B. A., Berggård I., Edelman G. M. 2 -Microglobulin--a free immunoglobulin domain. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1697–1701. doi: 10.1073/pnas.69.7.1697. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smithies O., Poulik M. D. Initiation of protein synthesis at an unusual position in an immunoglobulin gene? Science. 1972 Jan 14;175(4018):187–189. doi: 10.1126/science.175.4018.187. [DOI] [PubMed] [Google Scholar]