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. 1987 Nov;169(11):5314–5316. doi: 10.1128/jb.169.11.5314-5316.1987

Effects of segregation and selection on instability of plasmid pACYC184 in Escherichia coli B.

R E Lenski 1, J E Bouma 1
PMCID: PMC213944  PMID: 3312174

Abstract

We use a mathematical model to analyze the dynamics of loss of nonconjugative pACYC184 from populations of Escherichia coli B in glucose-limited continuous culture. This model incorporates both plasmid segregation and selection against plasmid carriage. It is concluded that there is intense selection against plasmid carriage (s = 0.3 per culture generation), which amplifies the frequency of segregants arising de novo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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