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. 1973 Nov 30;138(6):1356–1364. doi: 10.1084/jem.138.6.1356

MITOGENIC EFFECT BY LIPOPOLYSACCHARIDE AND POKEWEED LECTIN ON DENSITY-INHIBITED CHICK EMBRYO FIBROBLASTS

Antti Vaheri 1, Erkki Ruoslahti 1, Matti Sarvas 1, Marjatta Nurminen 1
PMCID: PMC2139454  PMID: 4762551

Abstract

The B lymphocyte mitogens, bacterial lipopolysaccharide (LPS), pokeweed lectin, and tuberculin, induced proliferation in density-inhibited monolayer cultures of chick embryo fibroblasts. The stimulation was seen both as an early increase in sugar uptake and cell volume and later as an increase in thymidine incorporation and cell number. The concentration of LPS maximally stimulating fibroblasts was remarkably low, about 0.1–1 ng/ml. LPS preparation with very different sugar chains gave quite similar results indicating that the architecture of the hydrophilic carbohydrate part is not critical for the mitogenic effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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