Abstract
Lewis kidneys were grafted into BN recipients and examined at daily intervals up to 6 days after grafting with immunofluorescent reagents. A horse antiserum specific for T lymphocytes revealed an increasing number of T lymphocytes in the cellular infiltrates of rejecting allografts. These were detectable 1 day after grafting, reached a maximum 3 days later, and were relatively diminished at 6 days. In control isografts and nonimmunological inflammations of kidney, a small number of dispersed T lymphocytes was seen. A rabbit antirat thymocyte antiserum, given to allografted BN rats, prolonged survival of the grafts and decreased the cellular infiltrate and the number of T lymphocytes in the infiltrates. We conclude that in graft rejection there is a flow of T lymphocytes into areas of tissue damage and these T lymphocytes are immunologically reactive to graft antigens.
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Selected References
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- Feldman J. D., Lee S. Renal homotransplantation in rats. I. Allogeneic recipients. J Exp Med. 1967 Nov 1;126(5):783–794. doi: 10.1084/jem.126.5.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Freedman L. R., Cerottini J. C., Brunner K. T. In vivo studies of the role of cytotoxic T cells in tumor allograft immunity. J Immunol. 1972 Dec;109(6):1371–1378. [PubMed] [Google Scholar]
- Lance E. M., Cooper S. Homing of specifically sensitized lymphocytes to allografts of skin. Cell Immunol. 1972 Sep;5(1):66–73. doi: 10.1016/0008-8749(72)90084-6. [DOI] [PubMed] [Google Scholar]
- Lee S. An improved technique of renal transplantation in the rat. Surgery. 1967 May;61(5):771–773. [PubMed] [Google Scholar]
- Rouse B. T., Wagner H. The in vivo activity of in vitro immunized mouse thymocytes. II. Rejection of skin allografts and graft-vs-host activity. J Immunol. 1972 Dec;109(6):1282–1289. [PubMed] [Google Scholar]
- Rouse B. T., Wells R. J., Warner N. L. Proportion of T and B lymphocytes in lesions of Marek's disease: theoretical implications for pathogenesis. J Immunol. 1973 Feb;110(2):534–539. [PubMed] [Google Scholar]
- Stobo J. D., Paul W. E. Functional heterogeneity of murine lymphoid cells. 3. Differential responsiveness of T cells to phytohemagglutinin and concanavalin A as a probe for T cell subsets. J Immunol. 1973 Feb;110(2):362–375. [PubMed] [Google Scholar]
- Stobo J. D., Paul W. E. Functional heterogeneity of murine lymphoid cells. II. Acquisition of mitogen responsiveness and of theta antigen during the ontogeny of thymocytes and "T" lymphocytes. Cell Immunol. 1972 Aug;4(4):367–380. doi: 10.1016/0008-8749(72)90039-1. [DOI] [PubMed] [Google Scholar]
- Stobo J. D., Paul W. E., Henney C. S. Functional heterogeneity of murine lymphoid cells. IV. Allogeneic mixed lymphocyte reactivity and cytolytic activity as functions of distinct T cell subsets. J Immunol. 1973 Mar;110(3):652–660. [PubMed] [Google Scholar]
- Williams R. M., Waksman B. H. Thymus-derived cells in the early phase of delayed tuberculin reactions. J Immunol. 1969 Dec;103(6):1435–1437. [PubMed] [Google Scholar]