Abstract
Immunization of BALB/c mice with Group A streptococcal vaccines leads to the induction of high levels of monoclonal antibody populations. Subsequent immunization of these mice with Group A-variant streptococcal vaccines induces a significant level of monoclonal antibody of A-variant antigen specificity revealed by labeled group A-variant polysaccharide. During these course Av and Av' immunizations, the monoclonal Group A-specific antibodies were also restimulated to levels usually higher than the variant-specific antibodies. With two exceptions, these homogeneous antibody populations were not cross-reactive in vitro with the related antigen. Such cross-stimulation of monoclonal antibodies was interpreted as a function of particular membrane properties of the Ig receptor-bearing memory cells which, for restimulation, would only require the structurally closely related antigen which serves as a backbone to the original antigen, and not necessarily the exact fit of the homologous immunodominant group.
Full Text
The Full Text of this article is available as a PDF (700.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ayoub E. M., Dudding B. A. Temperature-dependent variation in the synthesis of group-specific carbohydrate by streptococcal variant strains. I. Immunochemical studies. J Exp Med. 1973 Jul 1;138(1):117–129. doi: 10.1084/jem.138.1.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Braun D. G., Kelus A. S. Idiotypic specificity of rabbit antibodies to streptococcal group polysaccharides. J Exp Med. 1973 Nov 1;138(5):1248–1265. doi: 10.1084/jem.138.5.1248. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Braun D. G., Kindred B., Jacobson E. B. Streptococcal group A carbohydrate antibodies in mice: evidence for strain differences in magnitude and restriction of the response, and for thymus dependence. Eur J Immunol. 1972 Apr;2(2):138–143. doi: 10.1002/eji.1830020209. [DOI] [PubMed] [Google Scholar]
- Briles D. E., Krause R. M. Mouse antibodies to group A streptococcal carbohydrate; use of idiotypy to detect inbred strain specificity and to monitor spleen cell transfer in syngenetic mice. J Immunol. 1972 Dec;109(6):1311–1320. [PubMed] [Google Scholar]
- DIXON F. J., MAURER P. H. Specificity of the secondary response to protein antigens. J Immunol. 1955 Jun;74(6):418–431. [PubMed] [Google Scholar]
- Deutsch S., Bussard A. E. Original antigenic sin at the cellular level. I. Antibodies produced by individual cells against cross-reacting haptens. Eur J Immunol. 1972 Aug;2(4):374–378. doi: 10.1002/eji.1830020416. [DOI] [PubMed] [Google Scholar]
- Eichmann K. Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice. Eur J Immunol. 1972 Aug;2(4):301–307. doi: 10.1002/eji.1830020402. [DOI] [PubMed] [Google Scholar]
- FRANCIS T., Jr Influenza: the new acquayantance. Ann Intern Med. 1953 Aug;39(2):203–221. doi: 10.7326/0003-4819-39-2-203. [DOI] [PubMed] [Google Scholar]
- Fazekas de St Groth, Webster R. G. Disquisitions of Original Antigenic Sin. I. Evidence in man. J Exp Med. 1966 Sep 1;124(3):331–345. doi: 10.1084/jem.124.3.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fazekas de St Groth, Webster R. G. Disquisitions on Original Antigenic Sin. II. Proof in lower creatures. J Exp Med. 1966 Sep 1;124(3):347–361. doi: 10.1084/jem.124.3.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GILDEN R. V. Antibody responses after successive injections of related antigens. Immunology. 1963 Jan;6:30–36. [PMC free article] [PubMed] [Google Scholar]
- GILDEN R. V., TOKUDA S. Antibody quality after sequential immunization with related antigens. Science. 1963 Apr 26;140(3565):405–406. doi: 10.1126/science.140.3565.405-a. [DOI] [PubMed] [Google Scholar]
- Hanna M. G., Jr, Nettesheim P., Peters L. C. Evidence of functional microenvironments in lymphatic tissue response to antigen. Nat New Biol. 1971 Aug;232(33):204–206. doi: 10.1038/newbio232204a0. [DOI] [PubMed] [Google Scholar]
- Ivanyi J. Recall of antibody synthesis to the primary antigen following successive immunization with heterologous albumins. A two-cell theory of the original antigenic sin. Eur J Immunol. 1972 Aug;2(4):354–359. doi: 10.1002/eji.1830020411. [DOI] [PubMed] [Google Scholar]
- Jaton J. C., Braun D. G. Amino acid sequence of the N-terminal sixty-nine residues of heavy chain derived from a homogeneous rabbit antibody. Biochem J. 1972 Nov;130(2):539–546. doi: 10.1042/bj1300539. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KRAUSE R. M., MCCARTY M. Studies on the chemical structure of the streptococcal cell wall. I. The identification of a mucopeptide in the cell walls of groups A and A-variant streptococci. J Exp Med. 1961 Jul 1;114:127–140. doi: 10.1084/jem.114.1.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KRAUSE R. M. SYMPOSIUM ON RELATIONSHIP OF STRUCTURE OF MICROORGANISMS TO THEIR IMMUNOLOGICAL PROPERTIES. IV. ANTIGENIC AND BIOCHEMICAL COMPOSITION OF HEMOLYTIC STREPTOCOCCAL CELL WALLS. Bacteriol Rev. 1963 Dec;27:369–380. doi: 10.1128/br.27.4.369-380.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karakawa W. W., Lackland H., Krause R. M. Antigenic properties of the hexosamine polymer of streptococcal mucopeptide. J Immunol. 1967 Dec;99(6):1178–1182. [PubMed] [Google Scholar]
- Little J. R., Eisen H. N. Specificity of the immune response to the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl groups. Ligand binding and fluorescence properties of cross-reacting antibodies. J Exp Med. 1969 Feb 1;129(2):247–265. doi: 10.1084/jem.129.2.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCarty M. The streptococcal cell wall. Harvey Lect. 1971;65:73–96. [PubMed] [Google Scholar]