Abstract
CBA/HT6T6 bone marrow cells (1 x 107) or CBA/H bone marrow cells (1 x 107) plus CBA/HT6T6 thymus cells (5 x 107) were injected intravenously into lethally (800 R) irradiated CBA/H mice. Chromosome analyses of dividing cells in the host lymphoid and myeloid organs were performed at intervals after irradiation. Donor marrow cells settled and proliferated in the host bone marrow, spleen, and lymph nodes soon after injection, but donor marrow cells did not proliferate in the host thymus until day 10; then host-type cells were quickly replaced by donor-type cells in the thymus by day 20. On the other hand, donor thymus cells settled and proliferated in the host thymus and lymph nodes soon after injection but they gradually disappeared from these organs. On day 20, a few donor-type dividing cells (of thymus origin) were found in the host lymphoid and myeloid organs.
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Selected References
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- Claman H. N., Chaperon E. A., Triplett R. F. Immunocompetence of transferred thymus-marrow cell combinations. J Immunol. 1966 Dec;97(6):828–832. [PubMed] [Google Scholar]
- Claman H. N., Chaperon E. A., Triplett R. F. Thymus-marrow cell combinations. Synergism in antibody production. Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167–1171. doi: 10.3181/00379727-122-31353. [DOI] [PubMed] [Google Scholar]
- FORD C. E., HAMERTON J. L., BARNES D. W., LOUTIT J. F. Cytological identification of radiation-chimaeras. Nature. 1956 Mar 10;177(4506):452–454. doi: 10.1038/177452a0. [DOI] [PubMed] [Google Scholar]
- HARRIS J. E., FORD C. E., BARNES D. W., EVANS E. P. EVIDENCE FROM PARABIOSIS FOR AN AFFERENT STREAM OF CELLS. Nature. 1964 Feb 29;201:886–887. doi: 10.1038/201886a0. [DOI] [PubMed] [Google Scholar]
- Mitchell G. F., Miller J. F. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J Exp Med. 1968 Oct 1;128(4):821–837. doi: 10.1084/jem.128.4.821. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Takada A., Takada Y., Huang C. C., Ambrus J. L. Biphasic pattern of thymus regeneration after whole-body irradiation. J Exp Med. 1969 Mar 1;129(3):445–457. doi: 10.1084/jem.129.3.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Takada A., Takada Y. Proliferation of donor hematopoietic cells in lethally irradiated host mice. Transplantation. 1972 Mar;13(3):276–280. doi: 10.1097/00007890-197203000-00013. [DOI] [PubMed] [Google Scholar]
- Takada Y., Takada A. Proliferation of donor hematopoietic cells in irradiated and unirradiated host mice. Transplantation. 1971 Oct;12(4):334–338. doi: 10.1097/00007890-197110000-00021. [DOI] [PubMed] [Google Scholar]