Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1974 Feb 1;139(2):414–426. doi: 10.1084/jem.139.2.414

GENETIC INFLUENCES AFFECTING THE OCCURRENCE OF A DIABETES MELLITUS-LIKE DISEASE IN MICE INFECTED WITH THE ENCEPHALOMYOCARDITIS VIRUS

John E Craighead 1, Duncan A Higgins 1
PMCID: PMC2139533  PMID: 4359400

Abstract

The M variant of encephalomyocarditis virus produces a diabetes mellitus-like disease in DBA/2 mice but not in animals of the C3H strain. Fewer than one-third of infected F1 (DBA/2 x C3H) progeny exhibit the disease, whereas the prevalence in backcrosses (F1 x DBA/2, F1 x C3H) is comparable to the parental inbred strain. Thus, the mode of inheritance of the diabetic predisposition appears to be polygenic. DBA/2 animals develop striking inflammatory and necrotizing lesions of the islets of Langerhans; in contrast, alterations of the insular tissue in the C3H mice are minimal. Although metabolic abnormalities appear to be consequent to lesions of beta cells, the factors influencing the severity of these insular changes are incompletely understood.

Full Text

The Full Text of this article is available as a PDF (860.6 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boucher D. W., Notkins A. L. Virus-induced diabetes mellitus. I. Hyperglycemia and hypoinsulinemia in mice infected with encephalomyocarditis virus. J Exp Med. 1973 May 1;137(5):1226–1239. doi: 10.1084/jem.137.5.1226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Craighead J. E., McLane M. F. Diabetes mellitus: induction in mice by encephalomyocarditis virus. Science. 1968 Nov 22;162(3856):913–914. doi: 10.1126/science.162.3856.913. [DOI] [PubMed] [Google Scholar]
  3. Craighead J. E. Pathogenicity of the M and E variants of the encephalomyocarditis (EMC) virus. I. Myocardiotropic and neurotropic properties. Am J Pathol. 1966 Feb;48(2):333–345. [PMC free article] [PubMed] [Google Scholar]
  4. Craighead J. E. Pathogenicity of the M and E variants of the encephalomyocarditis (EMC) virus. II. Lesions of the pancreas, parotid and lacrimal glands. Am J Pathol. 1966 Mar;48(3):375–386. [PMC free article] [PubMed] [Google Scholar]
  5. Craighead J. E., Steinke J. Diabetes mellitus-like syndrome in mice infected with encephalomyocarditis virus. Am J Pathol. 1971 Apr;63(1):119–134. [PMC free article] [PubMed] [Google Scholar]
  6. Gamble D. R., Kinsley M. L., FitzGerald M. G., Bolton R., Taylor K. W. Viral antibodies in diabetes mellitus. Br Med J. 1969 Sep 13;3(5671):627–630. doi: 10.1136/bmj.3.5671.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gamble D. R., Taylor K. W. Coxsackie B virus and diabetes. Br Med J. 1973 Feb 3;1(5848):289–290. doi: 10.1136/bmj.1.5848.289-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gottlieb M. S., Root H. F. Diabetes mellitus in twins. Diabetes. 1968 Nov;17(11):693–704. doi: 10.2337/diab.17.11.693. [DOI] [PubMed] [Google Scholar]
  9. Hicks J. D., Burnet F. M. Renal lesions in the "auto-immune" mouse strains NZB and F1 NZBxNZW. J Pathol Bacteriol. 1966 Apr;91(2):467–476. doi: 10.1002/path.1700910221. [DOI] [PubMed] [Google Scholar]
  10. Kogon A., Spigland I., Frothingham T. E., Elveback L., Williams C., Hall C. E., Fox J. P. The virus watch program: a continuing surveillance of viral infections in metropolitan New York families. VII. Observations on viral excretion, seroimmunity, intrafamilial spread and illness association in coxsackie and echovirus infections. Am J Epidemiol. 1969 Jan;89(1):51–61. doi: 10.1093/oxfordjournals.aje.a120915. [DOI] [PubMed] [Google Scholar]
  11. Müntefering H., Schmidt W. A., Körber W. Zur Virusgenese des Diabetes mellitus bei der weissen Maus. Dtsch Med Wochenschr. 1971 Apr 16;96(16):693–697. doi: 10.1055/s-0028-1108315. [DOI] [PubMed] [Google Scholar]
  12. PARRY H. B. Scrapie: a transmissible and hereditary disease of sheep. Heredity (Edinb) 1962 Feb;17:75–105. doi: 10.1038/hdy.1962.4. [DOI] [PubMed] [Google Scholar]
  13. Pyke D. A., Cassar J., Todd J., Taylor K. W. Glucose tolerance and serum insulin in identical twins of diabetics. Br Med J. 1970 Dec 12;4(5736):649–651. doi: 10.1136/bmj.4.5736.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rowe W. P. Studies of genetic transmission of murine leukemia virus by AKR mice. I. Crosses with Fv-1 n strains of mice. J Exp Med. 1972 Nov 1;136(5):1272–1285. doi: 10.1084/jem.136.5.1272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Simpson N. E. Heritabilities of liability to diabetes when sex and age at onset are considered. Ann Hum Genet. 1969 Jan;32(3):283–303. doi: 10.1111/j.1469-1809.1969.tb00077.x. [DOI] [PubMed] [Google Scholar]
  16. Tattersall R. B., Pyke D. A. Diabetes in identical twins. Lancet. 1972 Nov 25;2(7787):1120–1125. doi: 10.1016/s0140-6736(72)92720-1. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES