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. 1974 Mar 1;139(3):785–790. doi: 10.1084/jem.139.3.785

INHIBITION OF A T-CELL-DEPENDENT IMMUNE RESPONSE IN VITRO BY THYMOMA CELL IMMUNOGLOBULIN

John W Stocker 1, John J Marchalonis 1, Alan W Harris 1
PMCID: PMC2139540  PMID: 4591179

Abstract

Concentrated medium obtained from cultures of a continuous thymus-derived mouse lymphoma cell line (WEHI-22.1) was found to inhibit a T-cell-dependent (antidonkey red blood cell), but not a T-cell-independent (anti-DNP) immune response in vitro. Passage of such a concentrate through an anti-mouse Ig immunoadsorbent column removed its inhibitory activity. It is suggested that the tumor cell Ig can compete with specific normal T-cell Ig in its collaborative function in immune responses. A similar mechanism may account for anergy associated with some human lymphoid neoplasms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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