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. 1974 Mar 1;139(3):457–466. doi: 10.1084/jem.139.3.457

LYMPHOID CELLS MEDIATING TUMOR-SPECIFIC CYTOTOXICITY TO CARCINOMA OF THE URINARY BLADDER

SEPARATION OF THE EFFECTOR POPULATION USING A SURFACE MARKER

C O'Toole 1, V Stejskal 1, P Perlmann 1, M Karlsson 1
PMCID: PMC2139543  PMID: 4591169

Abstract

Peripheral lymphocytes from patients with urinary bladder carcinoma and controls have been separated on the basis of rosette formation with sheep erythrocytes. The fractions were tested for tumor-specific cytotoxicity. The E rosette-forming cells of purity ⩾ 90% respond well in PHA-induced cytotoxicity but are totally inactive in the tumor assay. The non-E rosette-forming cells (purity ⩾ 91%) give enhanced activity in the tumor-specific cytotoxicity as well as in antibody-mediated target cell lysis in a model system. These data support the notion that the effector cells in cell-mediated immunity to carcinoma of the urinary bladder are members of the nonthymus-derived population of peripheral lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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