Abstract
Cellular responses in vitro to H-2D region histocompatibility antigens were demonstrated to be under the genetic control of two or three (P = 0.013) independently segregating loci. The H-2 region itself accounts for one of these loci, however, its activity appears to be dependent upon an association with other non-H-2-associated genetic information. The ability to stimulate a response and to respond to that stimulus are two separate genetic functions in certain MLR combinations. The stimuli in our studies were products of the H-2D region and cell donors must differ at that region in order for a response to occur. The control of the level of responses was determined by other genetic material. Differences at these "response loci" were not necessary for the induction of a proliferative response in the mixed lymphocyte cultures.
Full Text
The Full Text of this article is available as a PDF (634.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Amos D. B. The inheritance of leukocyte antigens. Transplantation. 1967 Jul;5(4 Suppl):1015–1023. [PubMed] [Google Scholar]
- Bach F. H., Widmer M. B., Bach M. L., Klein J. Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse. J Exp Med. 1972 Dec 1;136(6):1430–1444. doi: 10.1084/jem.136.6.1430. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Graff R. J., Hildemann W. H., Snell G. D. Histocompatibility genes of mice. VI. Allografts in mice congenic at various non-H-2 histocompatibility loci. Transplantation. 1966 Jul;4(4):425–437. [PubMed] [Google Scholar]
- Grumet F. C., McDevitt H. O. Genetic control of the immune response. Relationship between the immune response-1 gene(s) and individual H-2 antigenic specificities. Transplantation. 1972 Feb;13(2):171–173. doi: 10.1097/00007890-197202000-00019. [DOI] [PubMed] [Google Scholar]
- Jeekel J. J., McKenzie I. F., Winn H. J. Immunological enhancement of skin grafts in the mouse. J Immunol. 1972 Apr;108(4):1017–1024. [PubMed] [Google Scholar]
- Klein J., Shreffler D. C. Evidence supporting a two-gene model for the H-2 histocompatibility system of the mouse. J Exp Med. 1972 Apr 1;135(4):924–937. doi: 10.1084/jem.135.4.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lieberman R., Paul W. E., Humphrey W., Jr, Stimpfling J. H. H-2-linked immune response (Ir) genes. Independent loci for Ir-IgG and Ir-IgA genes. J Exp Med. 1972 Nov 1;136(5):1231–1240. doi: 10.1084/jem.136.5.1231. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Plate J. M., McKenzie I. F. "B"-cell stimulation of allogeneic T-cell proliferation in mixed lymphocyte cultures. Nat New Biol. 1973 Oct 24;245(147):247–249. doi: 10.1038/newbio245247a0. [DOI] [PubMed] [Google Scholar]
- Plate J. M. Mixed lymphocyte culture responses of mice: an analysis of the contribution of allelic differences at the various loci known to exist within the H-2 complex. Transplant Proc. 1973 Dec;5(4):1351–1359. [PubMed] [Google Scholar]
- Sachs D. H., Winn H. J., Russell P. S. The immunologic response to xenografts. Recognition of mouse H-2 histocompatibility antigens by the rat. J Immunol. 1971 Aug;107(2):481–492. [PubMed] [Google Scholar]
- Stimpfling J. H. Recombination within a histocompatibility locus. Annu Rev Genet. 1971;5:121–142. doi: 10.1146/annurev.ge.05.120171.001005. [DOI] [PubMed] [Google Scholar]
- Yunis E. J., Amos D. B. Three closely linked genetic systems relevant to transplantation. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3031–3035. doi: 10.1073/pnas.68.12.3031. [DOI] [PMC free article] [PubMed] [Google Scholar]