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. 1974 Apr 1;139(4):957–968. doi: 10.1084/jem.139.4.957

RELATIONSHIP BETWEEN HL-A ANTIGENS AND β2-MICROGLOBULIN AS STUDIED BY IMMUNOFLUORESCENCE ON THE LYMPHOCYTE MEMBRANE

C Neauport-Sautes 1, A Bismuth 1, F M Kourilsky 1, Y Manuel 1
PMCID: PMC2139575  PMID: 4131515

Abstract

The antibody-induced redistribution of β2-microglobulin (β2-µ) and HL-A antigens on the surface of living lymphocytes was studied by immunofluorescence. When all β2-µ was redistributed on the lymphocyte membrane by specific rabbit antibodies and goat antirabbit Ig conjugates, the HL-A antigens were no more detectable with anti-HL-A conjugates outside the β2-µ caps already formed. However, the redistribution of HL-A antigens fails to provoke the redistribution of all detectable β2-µ molecules. These results suggest that HL-A antigens may be associated with β2-µ at the cell surface, but that all β2-µ molecules are not bound to HL-A antigens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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