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. 1974 Aug 1;140(2):410–425. doi: 10.1084/jem.140.2.410

RENAL DEPOSITION OF SOLUBLE IMMUNE COMPLEXES IN MICE BEARING B-16 MELANOMA

CHARACTERIZATION OF COMPLEXES AND RELATIONSHIP TO TUMOR PROGRESS

Paula K F Poskitt 1, Thomas R Poskitt 1, John H Wallace 1
PMCID: PMC2139594  PMID: 4603012

Abstract

Histologic and immunofluorescence studies of the kidneys of mice bearing a progressive melanoma show a proliferative glomerulonephritis associated with immune complex deposition in the mesangium and along the glomerular basement membrane This immune complex disease is distinct from the age-associated disease of the C57BL/6J host strain and the complexes can be shown to consist of soluble tumor antigen and antitumor antibody. Furthermore, the intensity of IgG complex deposition correlates directly with tumor progress (size and metastases) and inversely with mononuclear leukocyte infiltration of the tumor. In vitro assays for lymphocyte cytotoxicity and humoral antibody were found to be less reliable indicators of tumor progress. The possible role of circulating soluble tumor antigen in modifying the immune response to tumors is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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