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. 1974 Oct 1;140(4):895–903. doi: 10.1084/jem.140.4.895

MEMBRANE IMMUNOGLOBULINS OF B LYMPHOCYTES

Inability to Detect Certain Characteristic IgM and IgD Antigens

S M Fu 1, H G Kunkel 1
PMCID: PMC2139633  PMID: 4139226

Abstract

Hemagglutination and fluorescent antibody studies have provided strong evidence for the unavailability or absence of specific antigenic sites on membrane-bound IgM which are present in serum and intracellular IgM. Antisera specific for different parts of the molecule indicated that a portion but not all of the Fc was involved. Absorption experiments with normal and leukemic viable B lymphocytes failed to remove a population of Fc antibodies found in IgM-specific antisera. Similar findings were made for IgD, the other major membrane immunoglobulin of human peripheral blood B cells. Various interpretations of these observations are discussed. The most likely possibility appears that the C-terminal portion of the heavy chains of the immunoglobulin molecule is buried in the membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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