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. 1974 Jun 1;139(6):1499–1512. doi: 10.1084/jem.139.6.1499

GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE

II. RELATIONSHIP BETWEEN IgM IMMUNOGLOBULIN LEVELS AND THE ABILITY TO GIVE AN IgM ANTIBODY RESPONSE

Diana F Amsbaugh 1, Carl T Hansen 1, Benjamin Prescott 1, Philip W Stashak 1, Richard Asofsky 1, Phillip J Baker 1
PMCID: PMC2139690  PMID: 4151455

Abstract

Serum IgM immunoglobulin levels and antibody responses to an optimally immunogenic dose of Type III pneumococcal polysaccharide (SSS-III) were assessed for F1, F2, and backcross progeny derived from crosses between high responding BALB/cAnN (B) and low responding CBA/HN (C) mice. The results obtained confirmed our original hypothesis, namely, that a major component, present on the X chromosome, governs the ability to respond to SSS-III in a decisive manner. Although all low responding C mice had low IgM levels, both intermediate and high responders had high IgM levels of the same magnitude. Treatment with bacterial lipopolysaccharides (LPS) resulted in a significant increase in the IgM levels of low responding C mice. While the IgM levels attained were similar to those of high responding B mice, not given LPS, no antibody specific for LPS appeared to be produced. These findings suggest that C mice are unable to make an IgM antibody response to SSS-III and other polysaccharide antigens, despite the fact that they possess the capacity to synthesize normal amounts of IgM immunoglobulin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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