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. 1974 Nov 30;140(6):1457–1467. doi: 10.1084/jem.140.6.1457

HOST GENETIC CONTROL OF RECOVERY FROM FRIEND LEUKEMIA VIRUS-INDUCED SPLENOMEGALY

Mapping of a Gene Within the Major Histocompatability Complex

Bruce Chesebro 1, Kathy Wehrly 1, Jack Stimpfling 1
PMCID: PMC2139745  PMID: 4430891

Abstract

The influence of the major mouse histocompatibility gene complex (H-2) on the response of mice to Friend leukemia virus was studied in F1 congenic mice differing only at genes within the H-2 complex. F1 mice which were H-2b/b had a high incidence of recovery from splenomegaly compared to H-2b/d or H-2b/a mice. In mice with recombinations within the H-2 complex a gene (designated RFV-1), responsible for the Friend virus recovery effect, was found to map near or within the D region of serologically detectable transplantation antigens. Because the incidence of recovery was much higher in F1 H-2b/b mice than in parental H-2b/b mice, other non-H-2 host genetic factors also appear to be important to expression of recovery in H-2b/b F1 mice. The mechanisms of action of these genes remain unknown.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AXELRAD A. A., STEEVES R. A. ASSAY FOR FRIEND LEUKEMIA VIRUS: RAPID QUANTITATIVE METHOD BASED ON ENUMERATION OF MACROSCOPIC SPLEEN FOCI IN MICE. Virology. 1964 Nov;24:513–518. doi: 10.1016/0042-6822(64)90199-0. [DOI] [PubMed] [Google Scholar]
  2. Benacerraf B., McDevitt H. O. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. doi: 10.1126/science.175.4019.273. [DOI] [PubMed] [Google Scholar]
  3. Dawson P. J., Fieldsteel A. H. The influence of age on chronic remittent Friend disease. Cancer Res. 1971 Jul;31(7):974–980. [PubMed] [Google Scholar]
  4. Dawson P. J., Tacke R. B., Fieldsteel A. H. Relationship between Friend virus and an associated lymphatic leukaemia virus. Br J Cancer. 1968 Sep;22(3):569–576. doi: 10.1038/bjc.1968.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ellman L., Green I., Martin W. J. Histocompatibility genes, immune responsiveness, and leukaemia. Lancet. 1970 May 23;1(7656):1104–1106. doi: 10.1016/s0140-6736(70)92767-4. [DOI] [PubMed] [Google Scholar]
  6. FRIEND C. Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia. J Exp Med. 1957 Apr 1;105(4):307–318. doi: 10.1084/jem.105.4.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Grumet F. C., Coukell A., Bodmer J. G., Bodmer W. F., McDevitt H. O. Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus. A possible genetic predisposition to disease. N Engl J Med. 1971 Jul 22;285(4):193–196. doi: 10.1056/NEJM197107222850403. [DOI] [PubMed] [Google Scholar]
  8. Klein J., Shreffler D. C. Evidence supporting a two-gene model for the H-2 histocompatibility system of the mouse. J Exp Med. 1972 Apr 1;135(4):924–937. doi: 10.1084/jem.135.4.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LILLY F., BOYSE E. A., OLD L. J. GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS. Lancet. 1964 Dec 5;2(7371):1207–1209. doi: 10.1016/s0140-6736(64)91043-8. [DOI] [PubMed] [Google Scholar]
  10. Lieberman R., Paul W. E., Humphrey W., Jr, Stimpfling J. H. H-2-linked immune response (Ir) genes. Independent loci for Ir-IgG and Ir-IgA genes. J Exp Med. 1972 Nov 1;136(5):1231–1240. doi: 10.1084/jem.136.5.1231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lilly F. Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice. J Natl Cancer Inst. 1970 Jul;45(1):163–169. [PubMed] [Google Scholar]
  12. Lilly F., Steeves R. A. B-tropic Friend virus: a host-range pseudotype of spleen focus-forming virus (SFFV). Virology. 1973 Oct;55(2):363–370. doi: 10.1016/0042-6822(73)90176-1. [DOI] [PubMed] [Google Scholar]
  13. Lilly F. The effect of histocompatibility-2 type on response to friend leukemia virus in mice. J Exp Med. 1968 Mar 1;127(3):465–473. doi: 10.1084/jem.127.3.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lilly F. The role of genetics in Gross virus leukemogenesis. Bibl Haematol. 1970;(36):213–220. doi: 10.1159/000391710. [DOI] [PubMed] [Google Scholar]
  15. McDevitt H. O., Bodmer W. F. Protein clinical manifestations of primary tumors of the heart. Am J Med. 1972 Jan;52(1):1–8. doi: 10.1016/0002-9343(72)90002-2. [DOI] [PubMed] [Google Scholar]
  16. McDevitt H. O., Deak B. D., Shreffler D. C., Klein J., Stimpfling J. H., Snell G. D. Genetic control of the immune response. Mapping of the Ir-1 locus. J Exp Med. 1972 Jun 1;135(6):1259–1278. doi: 10.1084/jem.135.6.1259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Nandi S. The histocompatability-2 locus and susceptibility to bittner virus borne by red blood cells in mice. Proc Natl Acad Sci U S A. 1967 Aug;58(2):485–492. doi: 10.1073/pnas.58.2.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. ODAKA T., EDAKA T., YAMAMOTTO T. Inheritance of susceptibility to Friend mouse leukemia virus. Jpn J Exp Med. 1962 Oct;32:405–413. [PubMed] [Google Scholar]
  19. Odaka T. Inheritance of susceptibility to Friend mouse leukemia virus. X. Separate genetic control of two viruses in Friend virus preparation. Int J Cancer. 1973 May;11(3):567–574. doi: 10.1002/ijc.2910110308. [DOI] [PubMed] [Google Scholar]
  20. Pincus T., Rowe W. P., Lilly F. A major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to friend murine leukemia virus. J Exp Med. 1971 Jun 1;133(6):1234–1241. doi: 10.1084/jem.133.6.1234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rachelefsky G. S., Terasaki P. I., Katz R., Stiehm E. R. Increased prevalence of W27 in juvenile rheumatoid arthritis. N Engl J Med. 1974 Apr 18;290(16):892–893. doi: 10.1056/NEJM197404182901608. [DOI] [PubMed] [Google Scholar]
  22. Sato H., Boyse E. A., Aoki T., Iritani C., Old L. J. Leukemia-associated transplantation antigens related to murine leukemia virus. The X.1 system: immune response controlled by a locus linked to H-2. J Exp Med. 1973 Sep 1;138(3):593–606. doi: 10.1084/jem.138.3.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Steeves R. A., Eckner R. J., Bennett M., Mirand E. A., Trudel P. J. Isolation and characterization of a lymphatic leukemia virus in the Friend virus complex. J Natl Cancer Inst. 1971 Jun;46(6):1209–1217. [PubMed] [Google Scholar]
  24. Steeves R. A., Eckner R. J. Host-induced changes in infectivity of Friend spleen focus-forming virus. J Natl Cancer Inst. 1970 Mar;44(3):587–594. [PubMed] [Google Scholar]
  25. Stimpfling J. H., Reichert A. E. Strain C57BL-10ScSn and its congenic resistant sublines. Transplant Proc. 1970 Mar;2(1):39–47. [PubMed] [Google Scholar]
  26. Tennant J. R., Snell G. D. The H-2 locus and viral leukemogenesis as studied in congenic strains of mice. J Natl Cancer Inst. 1968 Aug;41(2):597–604. [PubMed] [Google Scholar]

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