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. 1974 Nov 30;140(6):1660–1675. doi: 10.1084/jem.140.6.1660

GENETIC CONTROL OF THE ANTIBODY RESPONSE TO POLY-L(TYR,GLU)-POLY-D,L-ALA--POLY-L-LYS IN C3H↔CWB TETRAPARENTAL MICE

Kathleen B Bechtol 1, John H Freed 1, Leonard A Herzenberg 1, Hugh O McDevitt 1
PMCID: PMC2139758  PMID: 4139235

Abstract

In order to further delineate the mechanisms underlying genetic unresponsiveness, tetraparental mice were constructed from immune response-1A gene high responder and low responder parental genotypes, then were immunized with poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys ((T,G)-A--L). An analysis of the total serum allotype mixture and of the antigen-binding capacity of the separated allotypes demonstrated that in the milieu of a tetraparental mouse, both high and low responder B cells could be stimulated equally to produce identical high titered anti-(T,G)-A--L responses. Furthermore, these studies show that effective stimulation could occur across a histocompatibility disparity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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