Abstract
A genetic recombination study of an industrial strain of Streptomyces avermitilis which produces avermectin is described. A genetic map has been constructed by analysis of haploid recombinants and linkage relationships of 16 marker loci. Fifteen avermectin-nonproducing mutants, produced by mutagenesis, were classified into two phenotypically different groups, of which one produced avermectin aglycon and the other was able to convert avermectin aglycon to avermectins. Two different mutants were found to map closely to each other.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baltz R. H., Seno E. T. Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin. Antimicrob Agents Chemother. 1981 Aug;20(2):214–225. doi: 10.1128/aac.20.2.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burg R. W., Miller B. M., Baker E. E., Birnbaum J., Currie S. A., Hartman R., Kong Y. L., Monaghan R. L., Olson G., Putter I. Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. Antimicrob Agents Chemother. 1979 Mar;15(3):361–367. doi: 10.1128/aac.15.3.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Coats J. H., Roeser J. Genetic recombination in Streptomyces bikiniensis var. zorbonensis. J Bacteriol. 1971 Mar;105(3):880–885. doi: 10.1128/jb.105.3.880-885.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Delić V., Hopwood D. A., Friend E. J. Mutangenesis by N-methyl-N'-nitro-N-nitrosoguanidine (NTG) in Streptomyces coelicolor. Mutat Res. 1970 Feb;9(2):167–182. doi: 10.1016/0027-5107(70)90055-2. [DOI] [PubMed] [Google Scholar]
- Friend E. J., Hopwood D. A. The linkage map of Streptomyces rimosus. J Gen Microbiol. 1971 Oct;68(2):187–197. doi: 10.1099/00221287-68-2-187. [DOI] [PubMed] [Google Scholar]
- Furumai T., Suzuki M. Studies on the biosynthesis of basic 16-membered macrolide antibiotic, platenomycins. I. Selection of and cosynthesis by non-platenomycin-producing mutants. J Antibiot (Tokyo) 1975 Oct;28(10):770–774. doi: 10.7164/antibiotics.28.770. [DOI] [PubMed] [Google Scholar]
- Hopwood D. A. Genetic analysis and genome structure in Streptomyces coelicolor. Bacteriol Rev. 1967 Dec;31(4):373–403. doi: 10.1128/br.31.4.373-403.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hopwood D. A., Harold R. J., Vivian A., Ferguson H. M. A new kind of fertility variant in Streptomyces coelicolor. Genetics. 1969 Jul;62(3):461–477. doi: 10.1093/genetics/62.3.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rudd B. A., Hopwood D. A. A pigmented mycelial antibiotic in Streptomyces coelicolor: control by a chromosomal gene cluster. J Gen Microbiol. 1980 Aug;119(2):333–340. doi: 10.1099/00221287-119-2-333. [DOI] [PubMed] [Google Scholar]
- Rudd B. A., Hopwood D. A. Genetics of actinorhodin biosynthesis by Streptomyces coelicolor A3(2). J Gen Microbiol. 1979 Sep;114(1):35–43. doi: 10.1099/00221287-114-1-35. [DOI] [PubMed] [Google Scholar]
- Schulman M. D., Valentino D., Hensens O. D., Zink D., Nallin M., Kaplan L., Ostlind D. A. Demethylavermectins. Biosynthesis, isolation and characterization. J Antibiot (Tokyo) 1985 Nov;38(11):1494–1498. doi: 10.7164/antibiotics.38.1494. [DOI] [PubMed] [Google Scholar]
- Weber J. M., Wierman C. K., Hutchinson C. R. Genetic analysis of erythromycin production in Streptomyces erythreus. J Bacteriol. 1985 Oct;164(1):425–433. doi: 10.1128/jb.164.1.425-433.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]