Abstract
1. Though thymus-fed salamander larvæ often metamorphose normally, thymus feeding sometimes retards and in rare cases inhibits metamorphosis completely. 2. The addition of normal food to a thymus diet abolishes the inhibitory effect of the thymus. 3. Addition of a small quantity of iodothyrin leads rapidly to precocious metamorphosis of thymus-fed larvæ. 4. The inhibitory effect of the thymus is not due to a specific inhibiting substance in the thymus, but to the absence from the thymus of a substance required to develop the thyroid to the secretory state.
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- Lenhart C. H. THE INFLUENCE UPON TADPOLES OF FEEDING DESICCATED THYROID GLAND IN VARIABLE AMOUNTS AND OF VARIABLE IODINE CONTENTS. J Exp Med. 1915 Dec 1;22(6):739–746. doi: 10.1084/jem.22.6.739. [DOI] [PMC free article] [PubMed] [Google Scholar]