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. 1938 May 20;21(5):575–582. doi: 10.1085/jgp.21.5.575

TRANSFORMATION OF SWINE PEPSINOGEN INTO SWINE PEPSIN BY CHICKEN PEPSIN

Roger M Herriott 1, Quentin R Bartz 1, John H Northrop 1
PMCID: PMC2141963  PMID: 19873066

Abstract

Activation of swine pepsinogen with chicken pepsin results in the formation of swine pepsin. Activation of chicken pepsinogen with swine pepsin results in the formation of chicken pepsin. The structure responsible for the species specificity of the enzyme is therefore present in the inactive precursor.

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Selected References

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  1. Herriott R. M., Northrop J. H. ISOLATION OF CRYSTALLINE PEPSINOGEN FROM SWINE GASTRIC MUCOSAE AND ITS AUTOCATALYTIC CONVERSION INTO PEPSIN. Science. 1936 May 15;83(2159):469–470. doi: 10.1126/science.83.2159.469. [DOI] [PubMed] [Google Scholar]

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