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. 1939 May 20;22(5):671–687. doi: 10.1085/jgp.22.5.671

MEMBRANE AND PROTOPLASM RESISTANCE IN THE SQUID GIANT AXON

Kenneth S Cole 1, Alan L Hodgkin 1
PMCID: PMC2142005  PMID: 19873126

Abstract

The direct current longitudinal resistance of the squid giant axon was measured as a function of the electrode separation. Large sea water electrodes were used and the inter-electrode length was immersed in oil. The slope of the resistance vs. separation curve is large for a small electrode separation, but becomes smaller and finally constant as the separation is increased. An analysis of the resistance vs. length curves gives the following results. The nerve membrane has a resistance of about 1000 ohm cm.2 The protoplasm has a specific resistance of about 1.4 times that of sea water. The resistance of the connective tissue sheath outside the fiber corresponds to a layer of sea water about 20µ in thickness. The characteristic length for the axon is about 2.3 mm. in oil and 6.0 mm. in sea water.

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Selected References

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  1. Rushton W. A. A physical analysis of the relation between threshold and interpolar length in the electric excitation of medullated nerve. J Physiol. 1934 Oct 17;82(3):332–352. doi: 10.1113/jphysiol.1934.sp003185. [DOI] [PMC free article] [PubMed] [Google Scholar]

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