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The Journal of General Physiology logoLink to The Journal of General Physiology
. 1943 Jan 20;26(3):325–331. doi: 10.1085/jgp.26.3.325

ON THE CALCULATION OF "TURNOVER TIME" AND "TURNOVER RATE" FROM EXPERIMENTS INVOLVING THE USE OF LABELING AGENTS

D B Zilversmit 1, C Entenman 1, M C Fishler 1
PMCID: PMC2142557  PMID: 19873346

Abstract

1. A new method for the determination of an immediate precursor of a substance occurring in the animal body is presented. 2. Calculations on the quantitative determination of the rate of turnover of a substance and their application to experiments involving the use of labeling agents are given. These calculations take into account loss of the isotopic substance by way of breakdown or transport.

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