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. 1995 Nov;4(11):2429–2432. doi: 10.1002/pro.5560041122

Structural similarities in the noncatalytic domains of phenylalanyl-tRNA and biotin synthetases.

M Safro 1, L Mosyak 1
PMCID: PMC2143022  PMID: 8563641

Abstract

Detailed comparison between the structures of the Escherichia coli biotin synthetase/repressor protein (BirA) and the recently solved Thermus thermophilus phenylalanyl-tRNA synthetase (PheRS) reveals significant similarities outside their respective catalytic domains. These comprise a DNA-binding alpha+beta domain and an Src-homology 3 (SH3)-like domain that were observed in both enzymes. This similarity provides a novel example in which all domains of one multidomain protein appear to be constituents of the other multidomain protein and supports a concept of a common ancestor for two different synthetase families.

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Selected References

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