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. 1996 Dec;5(12):2651–2652. doi: 10.1002/pro.5560051229

Saccharomyces cerevisiae mitochondria lack a bacterial-type sec machinery.

B S Glick 1, G Von Heijne 1
PMCID: PMC2143305  PMID: 8976575

Abstract

The bacterial Sec genes encode a generalized protein export machinery. Although the mitochondria present in eukaryotic cells are derived from bacterial ancestors, a comprehensive search of the complete genomic sequence for the eukaryotic yeast Saccharomyces cerevisiae did not reveal any close homologs of the bacterial Sec genes, strongly suggesting that yeast mitochondria lack a generalized bacterial-type export system. This finding has implications for the sorting of imported mitochondrial proteins to the intermembrane space compartment, and also for the insertion of mitochondrially encoded proteins into the inner membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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