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. 1996 Mar;5(3):507–510. doi: 10.1002/pro.5560050312

On the entropy of protein folding.

G I Makhatadze 1, P L Privalov 1
PMCID: PMC2143355  PMID: 8868487

Abstract

The failure to appreciate that the hydration of polar groups is a major contribution to the entropy of protein unfolding has led to considerable underestimates for the loss of configurational freedom when a protein chain folds.

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Selected References

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