Abstract
Streptomyces fradiae expressed an adaptive response to treatment with small doses of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) that caused a reduction in mutagenesis by treatment with larger doses of MNNG. Treatment of S. fradiae with high levels of MNNG in the presence of chloramphenicol caused enhancement of mutagenesis, independent of the adaptive response.
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Selected References
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- Baltz R. H. Genetic recombination in Streptomyces fradiae by protoplast fusion and cell regeneration. J Gen Microbiol. 1978 Jul;107(1):93–102. doi: 10.1099/00221287-107-1-93. [DOI] [PubMed] [Google Scholar]
- Baltz R. H., Seno E. T. Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin. Antimicrob Agents Chemother. 1981 Aug;20(2):214–225. doi: 10.1128/aac.20.2.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Baltz R. H., Seno E. T., Stonesifer J., Wild G. M. Biosynthesis of the macrolide antibiotic tylosin. A preferred pathway from tylactone to tylosin. J Antibiot (Tokyo) 1983 Feb;36(2):131–141. doi: 10.7164/antibiotics.36.131. [DOI] [PubMed] [Google Scholar]
- Baltz R. H., Stonesifer J. Mutagenic and error-free DNA repair in Streptomyces. Mol Gen Genet. 1985;200(3):351–355. doi: 10.1007/BF00425716. [DOI] [PubMed] [Google Scholar]
- Cerdá-Olmedo E., Hanawalt P. C. The replication of the Escherichia coli chromosome studied by sequential nitrosoguanidine mutagenesis. Cold Spring Harb Symp Quant Biol. 1968;33:599–607. doi: 10.1101/sqb.1968.033.01.066. [DOI] [PubMed] [Google Scholar]
- Delić V., Hopwood D. A., Friend E. J. Mutangenesis by N-methyl-N'-nitro-N-nitrosoguanidine (NTG) in Streptomyces coelicolor. Mutat Res. 1970 Feb;9(2):167–182. doi: 10.1016/0027-5107(70)90055-2. [DOI] [PubMed] [Google Scholar]
- Drake J. W., Baltz R. H. The biochemistry of mutagenesis. Annu Rev Biochem. 1976;45:11–37. doi: 10.1146/annurev.bi.45.070176.000303. [DOI] [PubMed] [Google Scholar]
- Godfrey O. W. Directed mutation in Streptomyces lipmanii. Can J Microbiol. 1974 Nov;20(11):1479–1485. doi: 10.1139/m74-231. [DOI] [PubMed] [Google Scholar]
- Lindahl T. DNA repair enzymes. Annu Rev Biochem. 1982;51:61–87. doi: 10.1146/annurev.bi.51.070182.000425. [DOI] [PubMed] [Google Scholar]
- McCarthy T. V., Karran P., Lindahl T. Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli. EMBO J. 1984 Mar;3(3):545–550. doi: 10.1002/j.1460-2075.1984.tb01844.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morohoshi F., Munakata N. Bacillus subtilis mutants deficient in the adaptive response to simple alkylating agents. J Bacteriol. 1985 Mar;161(3):825–830. doi: 10.1128/jb.161.3.825-830.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Randazzo R., Sciandrello G., Carere A., Bignami M., Velcich A., Sermonti G. Localized mutagenesis in Streptomyces coelicolor A3 (2). Mutat Res. 1976 Sep;36(3):291–302. doi: 10.1016/0027-5107(76)90239-6. [DOI] [PubMed] [Google Scholar]
- Sklar R. Enchancement of nitrosoguanidine mutagenesis by chloramphenicol in Escherichia coli K-12. J Bacteriol. 1978 Oct;136(1):460–462. doi: 10.1128/jb.136.1.460-462.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sklar R., Strauss B. Role of the uvrE gene product and of inducible O6-methylguanine removal in the induction of mutations by N-methyl-N'-nitro-N-nitrosoguanidine in Escherichia coli. J Mol Biol. 1980 Nov 15;143(4):343–362. doi: 10.1016/0022-2836(80)90217-x. [DOI] [PubMed] [Google Scholar]
- Stonesifer J., Baltz R. H. Mutagenic DNA repair in Streptomyces. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1180–1183. doi: 10.1073/pnas.82.4.1180. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Walker G. C. Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. Microbiol Rev. 1984 Mar;48(1):60–93. doi: 10.1128/mr.48.1.60-93.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Witkin E. M., Kogoma T. Involvement of the activated form of RecA protein in SOS mutagenesis and stable DNA replication in Escherichia coli. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7539–7543. doi: 10.1073/pnas.81.23.7539. [DOI] [PMC free article] [PubMed] [Google Scholar]