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. 1997 Jan;6(1):249–253. doi: 10.1002/pro.5560060128

SAM as a protein interaction domain involved in developmental regulation.

J Schultz 1, C P Ponting 1, K Hofmann 1, P Bork 1
PMCID: PMC2143507  PMID: 9007998

Abstract

More than 60 previously undetected SAM domain-containing proteins have been identified using profile searching methods. Among these are over 40 EPH-related receptor tyrosine kinases (RPTK), Drosophila bicaudal-C, a p53 from Loligo forbesi, and diacyglycerol-kinase isoform delta. This extended dataset suggests that SAM is an evolutionary conserved protein binding domain that is involved in the regulation of numerous developmental processes among diverse eukaryotes. A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell-cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine.

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Selected References

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