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. 1999 Jul;8(7):1500–1504. doi: 10.1110/ps.8.7.1500

Heat capacity change for ribonuclease A folding.

C N Pace 1, G R Grimsley 1, S T Thomas 1, G I Makhatadze 1
PMCID: PMC2144378  PMID: 10422839

Abstract

The change in heat capacity deltaCp for the folding of ribonuclease A was determined using differential scanning calorimetry and thermal denaturation curves. The methods gave equivalent results, deltaCp = 1.15+/-0.08 kcal mol(-1) K(-1). Estimates of the conformational stability of ribonuclease A based on these results from thermal unfolding are in good agreement with estimates from urea unfolding analyzed using the linear extrapolation method.

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Selected References

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