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. 1991 Jan;37:120–124.

Polypharmacy in the Elderly

Drug reactions and interaction in the aged

HD Sanders
PMCID: PMC2145157  PMID: 21234085

Abstract

The elderly tolerate smaller doses of most drugs, largely because changes in body fat content, water content, and muscle mass often lead to higher blood levels than in a young person of the same weight. Moreover, diminished renal blood flow and creatinine clearance decrease excretion of agents cleared by the kidney. This leads to an increased number of drug reactions and interactions and consequent hospital admissions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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