Abstract
Drug-induced iatrogenic disease is more common among elderly patients than in any other patient population. Factors associated with adverse drug reactions in the elderly include excessive and inappropriate prescribing practices (such as the failure to adjust drug dose to age or complex drug regimens), the aging process itself (altered pharmacokinetics and pharmacodynamics), and concurrent illness.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alexander N., Goodwin J. S., Currie C. Comparison of admission and discharge medications in two geriatric populations. J Am Geriatr Soc. 1985 Dec;33(12):827–832. doi: 10.1111/j.1532-5415.1985.tb05434.x. [DOI] [PubMed] [Google Scholar]
- Beers M. H., Ouslander J. G. Risk factors in geriatric drug prescribing. A practical guide to avoiding problems. Drugs. 1989 Jan;37(1):105–112. doi: 10.2165/00003495-198937010-00008. [DOI] [PubMed] [Google Scholar]
- Beers M., Avorn J., Soumerai S. B., Everitt D. E., Sherman D. S., Salem S. Psychoactive medication use in intermediate-care facility residents. JAMA. 1988 Nov 25;260(20):3016–3020. [PubMed] [Google Scholar]
- Boman K., Allgulander S., Skoglund M. Is maintenance digoxin necessary in geriatric patients? Acta Med Scand. 1981;210(6):493–495. doi: 10.1111/j.0954-6820.1981.tb09857.x. [DOI] [PubMed] [Google Scholar]
- Greenblatt D. J., Sellers E. M., Shader R. I. Drug therapy: drug disposition in old age. N Engl J Med. 1982 May 6;306(18):1081–1088. doi: 10.1056/NEJM198205063061804. [DOI] [PubMed] [Google Scholar]
- Montamat S. C., Cusack B. J., Vestal R. E. Management of drug therapy in the elderly. N Engl J Med. 1989 Aug 3;321(5):303–309. doi: 10.1056/NEJM198908033210507. [DOI] [PubMed] [Google Scholar]
- Nolan L., O'Malley K. Prescribing for the elderly: Part II. Prescribing patterns: differences due to age. J Am Geriatr Soc. 1988 Mar;36(3):245–254. doi: 10.1111/j.1532-5415.1988.tb01809.x. [DOI] [PubMed] [Google Scholar]
- Popplewell P. Y., Henschke P. J. Acute admissions to a geriatric assessment unit. Med J Aust. 1982 Apr 17;1(8):343–344. doi: 10.5694/j.1326-5377.1982.tb132344.x. [DOI] [PubMed] [Google Scholar]
- Ray W. A., Federspiel C. F., Schaffner W. A study of antipsychotic drug use in nursing homes: epidemiologic evidence suggesting misuse. Am J Public Health. 1980 May;70(5):485–491. doi: 10.2105/ajph.70.5.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Savin R. C., Horwitz S. N. Double-blind comparison of 2% ketoconazole cream and placebo in the treatment of tinea versicolor. J Am Acad Dermatol. 1986 Sep;15(3):500–503. doi: 10.1016/s0190-9622(86)70200-4. [DOI] [PubMed] [Google Scholar]
- Schmucker D. L. Aging and drug disposition: an update. Pharmacol Rev. 1985 Jun;37(2):133–148. [PubMed] [Google Scholar]
- Shamburek R. D., Farrar J. T. Disorders of the digestive system in the elderly. N Engl J Med. 1990 Feb 15;322(7):438–443. doi: 10.1056/NEJM199002153220705. [DOI] [PubMed] [Google Scholar]
- Skoll S. L., August R. J., Johnson G. E. Drug prescribing for the elderly in Saskatchewan during 1976. Can Med Assoc J. 1979 Oct 20;121(8):1074–1081. [PMC free article] [PubMed] [Google Scholar]
- Vestal R. F. Pharmacology and aging. J Am Geriatr Soc. 1982 Mar;30(3):191–200. doi: 10.1111/j.1532-5415.1982.tb01303.x. [DOI] [PubMed] [Google Scholar]
- Wallace S. M., Verbeeck R. K. Plasma protein binding of drugs in the elderly. Clin Pharmacokinet. 1987 Jan;12(1):41–72. doi: 10.2165/00003088-198712010-00004. [DOI] [PubMed] [Google Scholar]
- Williams F. M., Wynne H., Woodhouse K. W., Rawlins M. D. Plasma aspirin esterase: the influence of old age and frailty. Age Ageing. 1989 Jan;18(1):39–42. doi: 10.1093/ageing/18.1.39. [DOI] [PubMed] [Google Scholar]
- Williamson J., Chopin J. M. Adverse reactions to prescribed drugs in the elderly: a multicentre investigation. Age Ageing. 1980 May;9(2):73–80. doi: 10.1093/ageing/9.2.73. [DOI] [PubMed] [Google Scholar]