Abstract
Thiol compounds, such as glutathione, 2,3-dimercaptopropanol (BAL), propane-1,3-dithiol, and N-phenylaminopropanedithiol, were readily oxidized by x-rays, beta rays, and gamma rays. The ionic yield for this oxidation was about the same, 3 at pH 7, on irradiation with x-rays and with beta rays; it was 23 per cent less on irradiation with gamma rays. The ionic yield varied with the hydrogen ion concentration, increasing as the pH value increased. There was no reduction of oxidized glutathione on irradiation with dosages of x-rays and gamma rays which produced oxidation of the reduced compound. In the absence of oxygen, the oxidation of thiols by ionizing radiations was only 33 per cent of that obtained in the presence of dissolved oxygen. When the thiol solutions were irradiated in the presence of dissolved oxygen, catalase protected them from oxidation by 17 to 27 per cent.
Full Text
The Full Text of this article is available as a PDF (634.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARRON E. S. G., DICKMAN S. Studies on the mechanism of action of ionizing radiations; inhibition of enzymes by X-rays. J Gen Physiol. 1949 Mar 20;32(4):537–552. doi: 10.1085/jgp.32.4.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BARRON E. S. G., DICKMAN S. Studies on the mechanism of action of ionizing radiations; inhibition of sulfhydryl enzymes by alpha, beta, and gamma rays. J Gen Physiol. 1949 May 20;32(5):595–605. doi: 10.1085/jgp.32.5.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodward G. E. The effect of ultra-violet, radium and X-ray radiation on glutathione in pure solution. Biochem J. 1933;27(5):1411–1414. doi: 10.1042/bj0271411. [DOI] [PMC free article] [PubMed] [Google Scholar]