Abstract
Procaine, cocaine, pyribenzamine, antistine, and phosphate decrease the uptake of water by frog sartorii in a Ringer solution in which potassium has been substituted for sodium; all but the last two leave the swelling in hypotonic Ringer practically unaltered. They also decrease the depolarizing action of potassium. These effects are considered indicative of reduced membrane permeability to potassium.
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Selected References
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- Boyle P. J., Conway E. J. Potassium accumulation in muscle and associated changes. J Physiol. 1941 Aug 11;100(1):1–63. doi: 10.1113/jphysiol.1941.sp003922. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DUTTA N. K. Some pharmacological properties common to antihistamine compounds. Br J Pharmacol Chemother. 1949 Sep;4(3):281–289. doi: 10.1111/j.1476-5381.1949.tb00549.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHANES A. M. Electrical phenomena in nerve; crab nerve. J Gen Physiol. 1949 Sep;33(1):75–102. doi: 10.1085/jgp.33.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHANES A. M. Electrical phenomena in nerve; squid giant axon. J Gen Physiol. 1949 Sep;33(1):57–73. doi: 10.1085/jgp.33.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shanes A. M. An Experimental and Theoretical Approach to the Mechanism of Cocaine Action. Science. 1948 Jun 25;107(2791):679–681. doi: 10.1126/science.107.2791.679-a. [DOI] [PubMed] [Google Scholar]
- YONKMANN F. F., ROTH F. Local anesthetic properties of antistine and pyribenzamine hydrochloride. Curr Res Anesth Analg. 1949 MayâJun;28(3):170–173. [PubMed] [Google Scholar]