Abstract
The use of acetyl-3-pyridine and pyridine-3-sulfonic acid as analogues for nicotinic acid has been tested with tissue cultures of embryonic chick heart. Both roller tube and Carrel flask cultures were employed. Cell migration, appearance of the cells, and the uptake of tracer P32 were used as criteria for the action of the analogues. Migration of the cells could be inhibited by both compounds, but at different levels. Both produced abnormal types of cells, but not the same type of abnormality. Uptake of P32 was inhibited by both compounds. Addition of nicotinic acid failed to reverse the effects of the analogues at the concentrations used.
Full Text
The Full Text of this article is available as a PDF (306.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- HULL W., KIRK P. L. Tissue culture studies; growth of tissue in vitro as related to the direct measurement of P32 uptake. J Gen Physiol. 1950 Mar;33(4):343–348. doi: 10.1085/jgp.33.4.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SIGNOROTTI B., HULL W., KIRK P. L. Tissue culture studies; standardization of techniques for quantitative culturing. J Gen Physiol. 1950 Mar;33(4):315–325. doi: 10.1085/jgp.33.4.315. [DOI] [PMC free article] [PubMed] [Google Scholar]