Abstract
1. The effect of varying body temperature on the rate of amino acid incorporation into serum protein does not give support to the idea that the rate of this process is adjusted in vivo to restore those protein molecules destroyed by thermal denaturation. The experimentally observed Q10 was about 3.9. 2. When amino acids are injected into the blood of animals in a steady state of serum protein turnover, a period of time elapses before these amino acids can be found in the serum proteins. This has been called transit time. At a given temperature (31°) it is the same in rabbits, turtles, and Limulus (1 hour). In rabbits and turtles it has a Q10 of 3.2. It appears to be specifically related to the process of synthesis (or release) of serum proteins. 3. It was not possible to affect the transit time or the incorporation rate by the administration of amino acid analogues.
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- BORSOOK H., DEASY C. L., HAAGENSMIT A. J., KEIGHLEY G., LOWY P. H. Metabolism of C14 labeled glycine, L-histidine, L-leucine, and L-lysine. J Biol Chem. 1950 Dec;187(2):839–848. [PubMed] [Google Scholar]
- GREEN H., ANKER H. S. On the synthesis of antibody protein. Biochim Biophys Acta. 1954 Mar;13(3):365–373. doi: 10.1016/0006-3002(54)90343-1. [DOI] [PubMed] [Google Scholar]
- MILLER L. L., BLY C. G., WATSON M. L., BALE W. F. The dominant role of the liver in plasma protein synthesis; a direct study of the isolated perfused rat liver with the aid of lysine-epsilon-C14. J Exp Med. 1951 Nov;94(5):431–453. doi: 10.1084/jem.94.5.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PETERS T., Jr Evidence of intermediate compounds in serum albumin synthesis. J Biol Chem. 1953 Jan;200(1):461–470. [PubMed] [Google Scholar]