Skip to main content
NCBI home page
Anesthesia Progress logoLink to Anesthesia Progress
. 1987 Mar-Apr;34(2):51–57.

Analysis of Cardiovascular Changes and Arterial Blood Gases in Patients Resistant to Methohexital Anesthesia

Robert L Campbell, Ronald G Shamaskin, Vernon W Saunders
PMCID: PMC2148564  PMID: 3111313

Abstract

Two studies were done to evaluate the patient who appears to be clinically resistant to incremental methohexital infusion for general anesthesia. A retrospective study revealed that 9% of the 513 patients developed resistance to methohexital maintenance and required a volatile inhalation anesthetic supplement. The cardiovascular and arterial blood gas analysis in a prospective study failed to disclose any gross changes that would explain the physiology associated with patients resistant to methohexital anesthesia. To maintain adequate anesthesia depth, doses of methohexital ranged from .07 to .12 mg/kg/min or 4.1 to 8.2 mg/min.

Full text

PDF
51

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen G. D., Everett G. B., Kennedy W. J., Jr Cardiorespiratory effects of general anesthesia on outpatients: methohexital, nitrous oxide-oxygen, halothane. J Oral Surg. 1970 Nov;28(11):814–817. [PubMed] [Google Scholar]
  2. Casson W. R., Jones R. M. Cardiac rate and rhythm during anaesthesia for dental extraction. A comparison of halothane, enflurane and isoflurane. Br J Anaesth. 1985 May;57(5):476–481. doi: 10.1093/bja/57.5.476. [DOI] [PubMed] [Google Scholar]
  3. Chernow B., Balestrieri F., Ferguson C. D., Terezhalmy G. T., Fletcher J. R., Lake C. R. Local dental anesthesia with epinephrine. Minimal effects on the sympathetic nervous system or on hemodynamic variables. Arch Intern Med. 1983 Nov;143(11):2141–2143. doi: 10.1001/archinte.143.11.2141. [DOI] [PubMed] [Google Scholar]
  4. GARDOCKI J. F., YELNOSKY J. A STUDY OF SOME OF THE PHARMACOLOGIC ACTIONS OF FENTANYL CITRATE. Toxicol Appl Pharmacol. 1964 Jan;6:48–62. doi: 10.1016/0041-008x(64)90021-3. [DOI] [PubMed] [Google Scholar]
  5. Rollason W. N., Bennetts F. E., Clarke I. Cardiac dysrhythmias during outpatient dental anaesthesia with enflurane. The role of "beta blockade". Acta Anaesthesiol Scand. 1984 Oct;28(5):497–502. doi: 10.1111/j.1399-6576.1984.tb02106.x. [DOI] [PubMed] [Google Scholar]
  6. WHITWAM J. G., YOUNG D. S. OBSERVATIONS ON DENTAL ANAESTHESIA INTRODUCED WITH METHOHEXITONE. III. BLOOD PRESSURE CHANGES. Br J Anaesth. 1964 Apr;36:237–243. doi: 10.1093/bja/36.4.237. [DOI] [PubMed] [Google Scholar]
  7. Wise C. C., Robinson J. S., Heath M. J., Tomlin P. J. Physiological responses to intermittent methohexitone for conservative dentistry. Br Med J. 1969 May 31;2(5656):540–543. doi: 10.1136/bmj.2.5656.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Wulfsohn N. L., Joshi C. W. Methohexital induction dosage based on lean body mass. J Oral Surg. 1974 Jun;32(6):426–428. [PubMed] [Google Scholar]

Articles from Anesthesia Progress are provided here courtesy of American Dental Society of Anesthesiology

RESOURCES