Abstract
The purpose of this study was to measure the degree of anesthesia obtained with 2.2% lidocaine hydrocarbonate, 2.2% lidocaine hydrocarbonate with 1:100,000 epinephrine, and 2% lidocaine hydrochloride with 1:100,000 epinephrine for inferior alveolar nerve block. Using a repeated-measures design, 30 subjects randomly received an inferior alveolar injection of each solution over the course of three successive appointments. The first molar, first premolar, lateral incisor, and contralateral canine (control) were blindly tested with an Analytic Technology pulp tester at 3-min cycles for 60 min. Anesthetic success was defined as no subject response to the maximum output (80 reading) of the pulp tester within 16 min and maintenance of this reading for the remainder of the testing period. Although subjects felt numb subjectively, anesthetic success as defined here ranged from 3% to 10% for the plain lidocaine hydrocarbonate; for the lidocaine hydrocarbonate and lidocaine hydrochloride solutions with epinephrine, success ranged from 37% to 63%. We conclude that 2.2% lidocaine hydrocarbonate without vasoconstrictor is not as effective as the other two preparations for inferior alveolar nerve block. The 2.2% lidocaine hydrocarbonate with epinephrine and 2%.
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Selected References
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- Agren E., Danielsson K. Conduction block analgesia in the mandible. A comparative investigation of the techniques of Fischer and Gow-Gates. Swed Dent J. 1981;5(3):81–89. [PubMed] [Google Scholar]
- Bokesch P. M., Raymond S. A., Strichartz G. R. Dependence of lidocaine potency on pH and PCO2. Anesth Analg. 1987 Jan;66(1):9–17. [PubMed] [Google Scholar]
- CONDOURIS G. A., SHAKALIS A. POTENTIATION OF THE NERVE-DEPRESSANT EFFECT OF LOCAL ANAESTHETICS BY CARBON DIOXIDE. Nature. 1964 Oct 3;204:57–58. doi: 10.1038/204057a0. [DOI] [PubMed] [Google Scholar]
- Catchlove R. F. Potentiation of two different local anaesthetics by carbon dioxide. Br J Anaesth. 1973 May;45(5):471–474. doi: 10.1093/bja/45.5.471. [DOI] [PubMed] [Google Scholar]
- Catchlove R. F. The influence of CO 2 and pH on local anesthetic action. J Pharmacol Exp Ther. 1972 May;181(2):298–309. [PubMed] [Google Scholar]
- Dreven L. J., Reader A., Beck M., Meyers W. J., Weaver J. An evaluation of an electric pulp tester as a measure of analgesia in human vital teeth. J Endod. 1987 May;13(5):233–238. doi: 10.1016/s0099-2399(87)80097-3. [DOI] [PubMed] [Google Scholar]
- Gupta Y. K., Doval D. C., Nath C., Saimbi C. S., Saxena R. C. Evaluation of carbonated solution of xylocaine as local anaesthetic. Indian J Med Res. 1982 Apr;75:579–582. [PubMed] [Google Scholar]
- Hinkley S. A., Reader A., Beck M., Meyers W. J. An evaluation of 4% prilocaine with 1:200,000 epinephrine and 2% mepivacaine with 1:20,000 levonordefrin compared with 2% lidocaine with:100,000 epinephrine for inferior alveolar nerve block. Anesth Prog. 1991 May-Jun;38(3):84–89. [PMC free article] [PubMed] [Google Scholar]
- Kaufman E., Weinstein P., Milgrom P. Difficulties in achieving local anesthesia. J Am Dent Assoc. 1984 Feb;108(2):205–208. doi: 10.14219/jada.archive.1984.0470. [DOI] [PubMed] [Google Scholar]
- Strichartz G. Molecular mechanisms of nerve block by local anesthetics. Anesthesiology. 1976 Oct;45(4):421–441. doi: 10.1097/00000542-197610000-00012. [DOI] [PubMed] [Google Scholar]
- Vreeland D. L., Reader A., Beck M., Meyers W., Weaver J. An evaluation of volumes and concentrations of lidocaine in human inferior alveolar nerve block. J Endod. 1989 Jan;15(1):6–12. doi: 10.1016/S0099-2399(89)80091-3. [DOI] [PubMed] [Google Scholar]
