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. 1996 Spring;43(2):41–51.

The effects of the hypothalamus on hemodynamic changes elicited by vagal nerve stimulation.

H Niwa 1, Y Hirota 1, T Shibutani 1, K Sugiyama 1, H Matsuura 1
PMCID: PMC2148778  PMID: 10323125

Abstract

To investigate the means by which neurogenic shock or syncope occur in dentistry, we determined the hemodynamic response to the activation of vagal tone in cats while they were under emotional stress. The hypothalamus and the vagal nerve were electrically stimulated to produce emotional stress and to activate vagal tone, respectively. Hemodynamic changes were recorded during vagal stimulation (Va group) and during vagal stimulation preceded by hypothalamic stimulation (AH + Va group). Although blood pressure decreased in both groups, the degree of hypotensive response in the AH + Va group was greater than the response in the Va group. Total peripheral resistance (TPR) was reduced in the AH + Va group but was increased in the Va group. The blood flow to the skeletal muscles in the AH + Va group was greater than that of the Va group. Reduced TPR, which could be due to vasodilation in the skeletal muscles, was the cause of intensified hypotension in the AH + Va group. Clearly, the hypotension produced by vagal stimulation was worsened when it was preceded by hypothalamic stimulation; this occurrence could be related to the tendency of blood to flow to the skeletal muscles.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABRAHAMS V. C., HILTON S. M. THE ROLE OF ACTIVE MUSCLE VASODILATATION IN THE ALERTING STAGE OF THE DEFENCE REACTION. J Physiol. 1964 Jun;171:189–202. doi: 10.1113/jphysiol.1964.sp007371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Caraffa-Braga E., Granata L., Pinotti O. Changes in blood-flow distribution during acute emotional stress in dogs. Pflugers Arch. 1973 Mar 30;339(3):203–216. doi: 10.1007/BF00587372. [DOI] [PubMed] [Google Scholar]
  3. Dellow P. G., Morgan M. J. Trigeminal nerve inputs and central blood pressure change in the cat. Arch Oral Biol. 1969 Mar;14(3):295–300. doi: 10.1016/0003-9969(69)90232-5. [DOI] [PubMed] [Google Scholar]
  4. Djojosugito A. M., Folkow B., Kylstra P. H., Lisander B., Tuttle R. S. Differentiated interaction between the hypothalamic defence reaction and baroreceptor reflexes. I. Effects on heart rate and regional flow resistance. Acta Physiol Scand. 1970 Mar;78(3):376–385. doi: 10.1111/j.1748-1716.1970.tb04673.x. [DOI] [PubMed] [Google Scholar]
  5. Evans D. E., Gillis R. A. Reflux mechanisms involved in cardiac arrhythmias induced by hypothalamic stimulation. Am J Physiol. 1978 Feb;234(2):H199–H209. doi: 10.1152/ajpheart.1978.234.2.H199. [DOI] [PubMed] [Google Scholar]
  6. Folkow B., Lisander B., Tuttle R. S., Wang S. C. Changes in cardiac output upon stimulation of the hypothalamic defence area and the medullary depressor area in the cat. Acta Physiol Scand. 1968 Jan-Feb;72(1):220–233. doi: 10.1111/j.1748-1716.1968.tb03844.x. [DOI] [PubMed] [Google Scholar]
  7. Forsyth R. P. Hypothalamic control of the distribution of cardiac output in the unanesthetized rhesus monkey. Circ Res. 1970 Jun;26(6):783–794. doi: 10.1161/01.res.26.6.783. [DOI] [PubMed] [Google Scholar]
  8. Fuchs S. A., Edinger H. M., Siegel A. The organization of the hypothalamic pathways mediating affective defense behavior in the cat. Brain Res. 1985 Mar 18;330(1):77–92. doi: 10.1016/0006-8993(85)90009-5. [DOI] [PubMed] [Google Scholar]
  9. Fuchs S. A., Edinger H. M., Siegel A. The role of the anterior hypothalamus in affective defense behavior elicited from the ventromedial hypothalamus of the cat. Brain Res. 1985 Mar 18;330(1):93–107. doi: 10.1016/0006-8993(85)90010-1. [DOI] [PubMed] [Google Scholar]
  10. Hickam J. B., Cargill W. H., Golden A. CARDIOVASCULAR REACTIONS TO EMOTIONAL STIMULI. EFFECT ON THE CARDIAC OUTPUT, ARTERIOVENOUS OXYGEN DIFFERENCE, ARTERIAL PRESSURE, AND PERIPHERAL RESISTANCE. J Clin Invest. 1948 Mar;27(2):290–298. doi: 10.1172/JCI101946. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Humphreys P. W., Joels N., McAllen R. M. Modification of the reflex response to stimulation of carotid sinus baroreceptors during and following stimulation of the hypothalamic defence area in the cat. J Physiol. 1971 Jul;216(2):461–482. doi: 10.1113/jphysiol.1971.sp009535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Inselman B. R., Flynn J. P. Modulatory effects of preoptic stimulation on hypothalamically-elicited attack in cats. Brain Res. 1972 Jul 13;42(1):73–87. doi: 10.1016/0006-8993(72)90043-1. [DOI] [PubMed] [Google Scholar]
  13. James J. E., De Burgh Daly M. Reflex respiratory and cardiovascular effects of stimulation of receptors in the nose of the dog. J Physiol. 1972 Feb;220(3):673–696. doi: 10.1113/jphysiol.1972.sp009729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kumada M., Dampney R. A., Reis D. J. The trigeminal depressor response: a novel vasodepressor response originating from the trigeminal system. Brain Res. 1977 Jan 7;119(2):305–326. doi: 10.1016/0006-8993(77)90313-4. [DOI] [PubMed] [Google Scholar]
  15. Kylstra P. H., Lisander B. Differentiated interaction between the hypothalamic defence area and baroreceptor reflexes. II. Effects on aortic blood flow as related to work load on the left ventricle. Acta Physiol Scand. 1970 Mar;78(3):386–392. doi: 10.1111/j.1748-1716.1970.tb04674.x. [DOI] [PubMed] [Google Scholar]
  16. Maeda H., Maki S. A mapping study of hypothalamic defensive attack and related responses in cats. Neurosci Res. 1989 Jun;6(5):438–445. doi: 10.1016/0168-0102(89)90005-9. [DOI] [PubMed] [Google Scholar]
  17. Martin J., Sutherland C. J., Zbrozyna A. W. Habituation and conditioning of the defense reactions and their cardiovascular components in cats and dogs. Pflugers Arch. 1976 Sep 3;365(1):37–47. doi: 10.1007/BF00583626. [DOI] [PubMed] [Google Scholar]
  18. NAKAO H. Emotional behavior produced by hypothalamic stimulation. Am J Physiol. 1958 Aug;194(2):411–418. doi: 10.1152/ajplegacy.1958.194.2.411. [DOI] [PubMed] [Google Scholar]
  19. Romaniuk A. Representation of aggression and flight reactions in the hypothalamus of the cat. Acta Biol Exp (Warsz) 1965;25(3):177–186. [PubMed] [Google Scholar]
  20. SUGAYA E., AKIBA T., TSUCHIYA M., KIRYU Y., YASUDA M., YAMAGUCHI Y., FUJISHIRO Y. STUDIES ON ELECTROPHYSIOLOGICAL PROPERTIES OF VAGO-VAGAL REFLEX. Keio J Med. 1964 Jun;13:77–85. doi: 10.2302/kjm.13.77. [DOI] [PubMed] [Google Scholar]
  21. Smith O. A., Astley C. A., DeVito J. L., Stein J. M., Walsh K. E. Functional analysis of hypothalamic control of the cardiovascular responses accompanying emotional behavior. Fed Proc. 1980 Jun;39(8):2487–2494. [PubMed] [Google Scholar]
  22. Smith O. A., Hohimer A. R., Astley C. A., Taylor D. J. Renal and hindlimb vascular control during acute emotion in the baboon. Am J Physiol. 1979 Mar;236(3):R198–R205. doi: 10.1152/ajpregu.1979.236.3.R198. [DOI] [PubMed] [Google Scholar]
  23. Stoddard-Apter S. L., Siegel A., Levin B. E. Plasma catecholamine and cardiovascular responses following hypothalamic stimulation in the awake cat. J Auton Nerv Syst. 1983 Aug;8(4):343–360. doi: 10.1016/0165-1838(83)90029-2. [DOI] [PubMed] [Google Scholar]
  24. Stoddard S. L., Bergdall V. K., Townsend D. W., Levin B. E. Plasma catecholamines associated with hypothalamically-elicited defense behavior. Physiol Behav. 1986;36(5):867–873. doi: 10.1016/0031-9384(86)90445-2. [DOI] [PubMed] [Google Scholar]
  25. Stoddard S. L., Bergdall V. K., Townsend D. W., Levin B. E. Plasma catecholamines associated with hypothalamically-elicited flight behavior. Physiol Behav. 1986;37(5):709–715. doi: 10.1016/0031-9384(86)90176-9. [DOI] [PubMed] [Google Scholar]
  26. Suzuki M. [Influence of trigeminal stimulation on vagal outflow]. Nihon Jibiinkoka Gakkai Kaiho. 1966 Mar;69(3):536–542. doi: 10.3950/jibiinkoka.69.536. [DOI] [PubMed] [Google Scholar]
  27. Tashiro N., Hirata K., Maki S., Nakao H. Cardiac arrhythmias induced in cats by stimulation of the anteromedial hypothalamus. Int J Psychophysiol. 1988 Aug;6(3):231–240. doi: 10.1016/0167-8760(88)90009-8. [DOI] [PubMed] [Google Scholar]
  28. Yardley C. P., Hilton S. M. The hypothalamic and brainstem areas from which the cardiovascular and behavioural components of the defence reaction are elicited in the rat. J Auton Nerv Syst. 1986 Mar;15(3):227–244. doi: 10.1016/0165-1838(86)90066-4. [DOI] [PubMed] [Google Scholar]

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