Skip to main content
NCBI home page
The British Journal of Cancer. Supplement logoLink to The British Journal of Cancer. Supplement
. 1973 Aug;1:77–82.

Cellular Immunity to Breast Carcinoma and Malignant Melanoma

A J Cochran, R M Mackie, C E Thomas, R M Grant, D E Cameron-Mowat, W G S Spilg
PMCID: PMC2149076  PMID: 4804293

Abstract

We have examined the effect of extracts of benign and malignant tumours on the migration of leucocytes from the peripheral blood of 55 melanoma patients, 73 breast carcinoma patients and 162 control donors in the leucocyte migration test. The leucocytes from a majority of tumour bearing patients were inhibited on contact with extracts of histogenetically similar tumours but only occasionally by extracts of dissimilar tumours and preparations from non-neoplastic breast tissue. Control donor's leucocytes were rarely inhibited by any of the tissue extracts. In both patients with malignant melanoma and those with breast carcinoma there was a striking decline in the frequency of tumour extract mediated leucocyte migration inhibition in patients with metastases.

Full text

PDF
77

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen V., Bjerrum O., Bendixen G., Schiodt T., Dissing I. Effect of autologous mammary tumour extracts on human leukocyte migration in vitro. Int J Cancer. 1970 May 15;5(3):357–363. doi: 10.1002/ijc.2910050308. [DOI] [PubMed] [Google Scholar]
  2. Bendixen G., Egeberg J., Nerup J. The fate of corpuscular antigen in leukocyte migration cultures. Transplant Proc. 1972 Jun;4(2):253–258. [PubMed] [Google Scholar]
  3. Bendixen G. Specific inhibition of the in vitro migration of leucocytes in ulcerative colitis and Crohn's disease. Scand J Gastroenterol. 1967;2(3):214–221. doi: 10.3109/00365526709180072. [DOI] [PubMed] [Google Scholar]
  4. Black M. M., Leis H. P., Jr Cellular responses to autologous breast cancer tissue. Correlation with stage and lymphoreticuloendothelial reactive. Cancer. 1971 Aug;28(2):263–273. doi: 10.1002/1097-0142(197108)28:2<263::aid-cncr2820280202>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  5. Clausen J. E., Soborg M. In vitro detection of tuberculin hypersensitivity in man. Specific migration inhibition of white blood cells from tuberculin-positive persons. Acta Med Scand. 1969 Sep;186(3):227–230. [PubMed] [Google Scholar]
  6. Cochran A. J., Jehn U. W., Gothoskar B. P. Cell-mediated immunity in malignant melanoma. Lancet. 1972 Jun 17;1(7764):1340–1341. doi: 10.1016/s0140-6736(72)91070-7. [DOI] [PubMed] [Google Scholar]
  7. Cochran A. J., Klein E., Keissling R. Effect of immune factors on the motility of lymphoma cells. J Natl Cancer Inst. 1972 Jun;48(6):1657–1661. [PubMed] [Google Scholar]
  8. Cochran A. J., Spilg W. G., Mackie R. M., Thomas C. E. Postoperative depression of tumour-directed cell-mediated immunity in patients with malignant disease. Br Med J. 1972 Oct 14;4(5832):67–70. [PMC free article] [PubMed] [Google Scholar]
  9. Currie G. A., Lejeune F., Fairley G. H. Immunization with irradiated tumour cells and specific lymphocyte cytotoxicity in malignant melanoma. Br Med J. 1971 May 8;2(5757):305–310. doi: 10.1136/bmj.2.5757.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Deodhar S. D., Crile G., Jr, Esselstyn C. B., Jr Study of the tumor cell-lymphocyte interaction in patients with breast cancer. Cancer. 1972 May;29(5):1321–1325. doi: 10.1002/1097-0142(197205)29:5<1321::aid-cncr2820290529>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  11. Falk R. E., Thorsby E., Möller E., Möller G. In vitro assay of cell-mediated immunity: the inhibition of migration of sensitized human lymphocytes by HL-A antigens. Clin Exp Immunol. 1970 Apr;6(4):445–455. [PMC free article] [PubMed] [Google Scholar]
  12. Fass L., Herberman R. B., Ziegler J. L., Kiryabwire J. W. Cutaneous hypersensitivity reactions to autologous extracts of malignant melanoma cells. Lancet. 1970 Jan 17;1(7638):116–118. doi: 10.1016/s0140-6736(70)90467-8. [DOI] [PubMed] [Google Scholar]
  13. Faucault J. P., Bernard J. P., Potier J. C., Lecacheux C. Cytotoxic lymphocytes in melanoma patients. Int J Cancer. 1972 May 15;9(3):567–576. doi: 10.1002/ijc.2910090313. [DOI] [PubMed] [Google Scholar]
  14. Federlin K., Maini R. N., Russell A. S., Dumonde D. C. A micro-method for peripheral leucocyte migration in tuberculin sensitivity. J Clin Pathol. 1971 Sep;24(6):533–536. doi: 10.1136/jcp.24.6.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Fossati G., Canevari S., Della Porta G., Balzarini G. P., Veronesi U. Cellular immunity to human breast carcinoma. Int J Cancer. 1972 Sep 15;10(2):391–396. doi: 10.1002/ijc.2910100221. [DOI] [PubMed] [Google Scholar]
  16. Fossati G., Colnaghi M. I., Porta G. D., Cascinelli N., Veronesi U. Cellular and humoral immunity against human malignant melanoma. Int J Cancer. 1971 Sep 15;8(2):344–350. doi: 10.1002/ijc.2910080221. [DOI] [PubMed] [Google Scholar]
  17. GEORGE M., VAUGHAN J. H. In vitro cell migration as a model for delayed hypersensitivity. Proc Soc Exp Biol Med. 1962 Nov;111:514–521. doi: 10.3181/00379727-111-27841. [DOI] [PubMed] [Google Scholar]
  18. Girard J. P. Valeur du test d'inhibition de la migration des cellules lymphoïdes, in vitro, appliqué au diagnostic des allergies médicamenteuses. Schweiz Med Wochenschr. 1968 Oct 19;98(42):1655–1656. [PubMed] [Google Scholar]
  19. Halliday W. J., Webb M. Delayed hypersensitivity to chemically induced tumors in mice and correlation with an in vitro test. J Natl Cancer Inst. 1969 Jul;43(1):141–150. [PubMed] [Google Scholar]
  20. Kaltreider H. B., Soghor D., Taylor J. B., Decker J. L. Capillary tube migration for detection of human delayed hypersensitivity: difficulties encountered with "buffy coat" cells and tuberculin antigen. J Immunol. 1969 Aug;103(2):179–184. [PubMed] [Google Scholar]
  21. Klein E., Cochran A. J. Immunology and malignant disease. Haematologia (Budap) 1971;5(3):179–203. [PubMed] [Google Scholar]
  22. Klein G., Oettgen H. F. Immunologic factors involved in the growth of primary tumors in human or animal hosts. Cancer Res. 1969 Sep;29(9):1741–1746. [PubMed] [Google Scholar]
  23. Kronman B. S., Wepsic H. T., Churchill W. H., Jr, Zbar B., Borsos T., Rapp H. J. Tumor-specific antigens detected by inhibition of macrophage migration. Science. 1969 Jul 18;165(3890):296–297. doi: 10.1126/science.165.3890.296. [DOI] [PubMed] [Google Scholar]
  24. Lewis M. G., Ikonopisov R. L., Nairn R. C., Phillips T. M., Fairley G. H., Bodenham D. C., Alexander P. Tumour-specific antibodies in human malignant melanoma and their relationship to the extent of the disease. Br Med J. 1969 Sep 6;3(5670):547–552. doi: 10.1136/bmj.3.5670.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Lockshin M. D. Failure to demonstrate leukocyte migration inhibition in human tuberculin hypersensitivity. Proc Soc Exp Biol Med. 1969 Dec;132(3):928–930. doi: 10.3181/00379727-132-34339. [DOI] [PubMed] [Google Scholar]
  26. Mackie R. M., Spilg W. G., Thomas C. E., Cochran A. J. Cell-mediated immunity in patients with malignant melanoma. Br J Dermatol. 1972 Dec;87(6):523–528. doi: 10.1111/j.1365-2133.1972.tb07440.x. [DOI] [PubMed] [Google Scholar]
  27. Medzihradský J., Kalafut F. Inhibited migration of peritoneal exudate cells harvested from rats bearing syngeneic or autochthonous tumours. Neoplasma. 1972;19(2):147–149. [PubMed] [Google Scholar]
  28. Morton D. L., Eilber F. R., Malmgren R. A. Immune factors in human cancer: malignant melanomas, skeletal and soft tissue sarcomas. Prog Exp Tumor Res. 1971;14:25–42. doi: 10.1159/000392269. [DOI] [PubMed] [Google Scholar]
  29. Nordqvist B., Rorsman H. Leucocytic migration in vitro as an indicator of allergy in eczematous contact dermatitis. Trans St Johns Hosp Dermatol Soc. 1967;53(2):154–159. [PubMed] [Google Scholar]
  30. Segall A., Weiler O., Genin J., Lacour J., Lacour F. In vitro study of cellular immunity against autochthonous human cancer. Int J Cancer. 1972 Mar 15;9(2):417–425. doi: 10.1002/ijc.2910090221. [DOI] [PubMed] [Google Scholar]
  31. Smith M. G., Eddleston A. L., Dominguez J. A., Evans D. B., Bewick M., Williams R. Changes in leucocyte migration after renal transplantation. Br Med J. 1969 Nov 1;4(5678):275–278. doi: 10.1136/bmj.4.5678.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Soborg M., Bendixen G. Human lymphocyte migration as a parameter of hypersensitivity. Acta Med Scand. 1967 Feb;181(2):247–256. doi: 10.1111/j.0954-6820.1967.tb07255.x. [DOI] [PubMed] [Google Scholar]
  33. Soborg M. Interaction of human peripheral lymphocytes and granulocytes in the migration-inhibition reaction. Acta Med Scand. 1969 Mar;185(3):221–226. [PubMed] [Google Scholar]
  34. Thor D. E., Jureziz R. E., Veach S. R., Miller E., Dray S. Cell migration inhibition factor released by antigen from human peripheral lymphocytes. Nature. 1968 Aug 17;219(5155):755–757. doi: 10.1038/219755a0. [DOI] [PubMed] [Google Scholar]
  35. Thulin H., Zachariae H. The leucocyte migration test in chromium hypersensitivity. J Invest Dermatol. 1972 Feb;58(2):55–58. doi: 10.1111/1523-1747.ep12551476. [DOI] [PubMed] [Google Scholar]
  36. Whittaker M. G., Clark C. G. Depressed lymphocyte function in carcinoma of the breast. Br J Surg. 1971 Oct;58(10):717–720. doi: 10.1002/bjs.1800581002. [DOI] [PubMed] [Google Scholar]
  37. Wolberg W. H. Inhibition of migration of human autogenous and allogeneic leukocytes by extracts of patients' cancers. Cancer Res. 1971 Jun;31(6):798–802. [PubMed] [Google Scholar]

Articles from The British Journal of Cancer. Supplement are provided here courtesy of Cancer Research UK

RESOURCES