Skip to main content
NCBI home page
The British Journal of Cancer. Supplement logoLink to The British Journal of Cancer. Supplement
. 1988 Dec;9:5–8.

Unfinished business.

J Paul 1
PMCID: PMC2149116  PMID: 3254726

Abstract

The past 40 years have witnessed the development to maturity of molecular biology from its beginnings and determined attempts to apply this discipline in medicine, particularly to genetics, haematology, immunology and cancer research. However, although we have accumulated a detailed understanding of the genetic code and the mechanisms of the central dogma of molecular biology and have developed exquisitely sensitive and precise technologies, most recently represented by DNA recombinant techniques, many of the fundamental biological problems of 40 years ago still remain unsolved today. Some of these are listed and discussed.

Full text

PDF
5

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COLE R. J., EDWARDS R. G., PAUL J. CYTODIFFERENTIATION IN CELL COLONIES AND CELL STRAINS DERIVED FROM CLEAVING OVA AND BLASTOCYSTS OF THE RABBIT. Exp Cell Res. 1965 Feb;37:501–504. doi: 10.1016/0014-4827(65)90201-6. [DOI] [PubMed] [Google Scholar]
  2. Cole R. J., Paul J. The effects of erythropoietin on haem synthesis in mouse yolk sac and cultured foetal liver cells. J Embryol Exp Morphol. 1966 Apr;15(2):245–260. [PubMed] [Google Scholar]
  3. DAVIDSON J. N., PAUL J., THOMSON R. Y. Metabolic stability of DNA in fibroblast cultures. Biochim Biophys Acta. 1956 Dec;22(3):581–583. doi: 10.1016/0006-3002(56)90076-2. [DOI] [PubMed] [Google Scholar]
  4. Getz M. J., Birnie G. D., Young B. D., MacPhail E., Paul J. A kinetic estimation of base sequence complexity of nuclear poly(A)-containing RNA in mouse Friend cells. Cell. 1975 Feb;4(2):121–129. doi: 10.1016/0092-8674(75)90118-x. [DOI] [PubMed] [Google Scholar]
  5. Gilmour R. S., Allan M., Paul J. Accurate initiation of human epsilon-globin RNA synthesis by Escherichia coli RNA polymerase in isolated nuclei of K562 erythroleukemia cells. Proc Natl Acad Sci U S A. 1984 Jul;81(13):4051–4054. doi: 10.1073/pnas.81.13.4051. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harrison P. R., Birnie G. D., Hell A., Humphries S., Young B. D., Paul J. Kinetic studies of gene frequency. I. Use of a DNA copy of reticulocyte 9 S RNA to estimate globin gene dosage in mouse tissues. J Mol Biol. 1974 Apr 25;84(4):539–554. doi: 10.1016/0022-2836(74)90115-6. [DOI] [PubMed] [Google Scholar]
  7. Ottolenghi S., Lanyon W. G., Paul J., Williamson R., Weatherall D. J., Clegg J. B., Pritchard J., Pootrakul S., Boon W. H. The severe form of alpha thalassaemia is caused by a haemoglobin gene deletion. Nature. 1974 Oct 4;251(5474):389–392. doi: 10.1038/251389a0. [DOI] [PubMed] [Google Scholar]
  8. PAUL J., FOTTRELL P. F. Mechanism of D-glutamyltransferase repression in mammalian cells. Biochim Biophys Acta. 1963 Feb 12;67:334–336. doi: 10.1016/0006-3002(63)91836-5. [DOI] [PubMed] [Google Scholar]
  9. PAUL J. The cancer cell in vitro: a review. Cancer Res. 1962 May;22:431–440. [PubMed] [Google Scholar]
  10. Paul J., Gilmour R. S. Template activity of DNA is restricted in chromatin. J Mol Biol. 1966 Mar;16(1):242–244. doi: 10.1016/s0022-2836(66)80276-0. [DOI] [PubMed] [Google Scholar]
  11. Paul J., Hickey I. Haemoglobin synthesis in inducible, uninducible and hybrid Friend cell clones. Exp Cell Res. 1974 Jul;87(1):20–30. doi: 10.1016/0014-4827(74)90522-9. [DOI] [PubMed] [Google Scholar]
  12. Pragnell I. B., Ostertag W., Paul J. The expression of viral and globin genes during differentiation of the Friend cell. Exp Cell Res. 1977 Sep;108(2):269–278. doi: 10.1016/s0014-4827(77)80034-7. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Cancer. Supplement are provided here courtesy of Cancer Research UK

RESOURCES