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. 1984;6:13–18.

Introductory review: involvement of ADP-ribosylation in cellular recovery from some forms of DNA damage.

J Lunec
PMCID: PMC2149140  PMID: 6320850

Abstract

There is substantial evidence that ADP-ribosylation is stimulated in response to DNA strand breaks produced directly by a damaging agent or during excision repair processes. The report of a reduced stimulation of ADPRT activity in irradiated ataxia telangiectasia cells has recently stimulated a wide interest in the role of ADP-ribosylation in cellular radiation response. The resulting studies, some of which are presented at this conference, demonstrate that cellular recovery from radiation damage can be significantly impaired if ADP-ribosylation is inhibited to a sufficiently low level. The implication is that the repair of DNA lesions is affected. This review summarizes the involvement of the enzyme ADPRT and the extent of ADP-ribosylation in the repair of DNA damage and of cellular recovery.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Althaus F. R., Lawrence S. D., Sattler G. L., Pitot H. C. ADP-ribosyltransferase activity in cultured hepatocytes. Interactions with DNA repair. J Biol Chem. 1982 May 25;257(10):5528–5535. [PubMed] [Google Scholar]
  2. Althaus F. R., Lawrence S. D., Sattler G. L., Pitot H. C. The effect of nicotinamide on unscheduled DNA synthesis in cultured hepatocytes. Biochem Biophys Res Commun. 1980 Aug 14;95(3):1063–1070. doi: 10.1016/0006-291x(80)91581-8. [DOI] [PubMed] [Google Scholar]
  3. Benjamin R. C., Gill D. M. Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks. J Biol Chem. 1980 Nov 10;255(21):10502–10508. [PubMed] [Google Scholar]
  4. Berger N. A., Sikorski G. W. Nicotinamide stimulates repair of DNA damage in human lymphocytes. Biochem Biophys Res Commun. 1980 Jul 16;95(1):67–72. doi: 10.1016/0006-291x(80)90705-6. [DOI] [PubMed] [Google Scholar]
  5. Berger N. A., Sikorski G. W., Petzold S. J., Kurohara K. K. Defective poly(adenosine diphosphoribose) synthesis in xeroderma pigmentosum. Biochemistry. 1980 Jan 22;19(2):289–293. doi: 10.1021/bi00543a006. [DOI] [PubMed] [Google Scholar]
  6. Bohr V., Klenow H. 3-Aminobenzamide stimulates unscheduled DNA synthesis and rejoining of strand breaks in human lymphocytes. Biochem Biophys Res Commun. 1981 Oct 30;102(4):1254–1261. doi: 10.1016/s0006-291x(81)80146-5. [DOI] [PubMed] [Google Scholar]
  7. Butt T. R., Jump D. B., Smulson M. E. Nucleosome periodicity in HeLa cell chromatin as probed by micrococcal nuclease. Proc Natl Acad Sci U S A. 1979 Apr;76(4):1628–1632. doi: 10.1073/pnas.76.4.1628. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Creissen D., Shall S. Regulation of DNA ligase activity by poly(ADP-ribose). Nature. 1982 Mar 18;296(5854):271–272. doi: 10.1038/296271a0. [DOI] [PubMed] [Google Scholar]
  9. Durkacz B. W., Irwin J., Shall S. Inhibition of (ADP-ribose)n biosynthesis retards DNA repair but does not inhibit DNA repair synthesis. Biochem Biophys Res Commun. 1981 Aug 31;101(4):1433–1441. doi: 10.1016/0006-291x(81)91607-7. [DOI] [PubMed] [Google Scholar]
  10. Durkacz B. W., Omidiji O., Gray D. A., Shall S. (ADP-ribose)n participates in DNA excision repair. Nature. 1980 Feb 7;283(5747):593–596. doi: 10.1038/283593a0. [DOI] [PubMed] [Google Scholar]
  11. Durkacz B. W., Shall S., Irwin J. The effect of inhibition of (ADP-ribose)n biosynthesis on DNA repair assayed by the nucleoid technique. Eur J Biochem. 1981 Dec;121(1):65–69. doi: 10.1111/j.1432-1033.1981.tb06430.x. [DOI] [PubMed] [Google Scholar]
  12. Edwards M. J., Taylor A. M. Unusual levels of (ADP-ribose)n and DNA synthesis in ataxia telangiectasia cells following gamma-ray irradiation. Nature. 1980 Oct 23;287(5784):745–747. doi: 10.1038/287745a0. [DOI] [PubMed] [Google Scholar]
  13. Giri C. P., West M. H., Ramirez M. L., Smulson M. Nuclear protein modification and chromatin substructure. 2. Internucleosomal localization of poly(adenosine diphosphate-ribose) polymerase. Biochemistry. 1978 Aug 22;17(17):3501–3504. doi: 10.1021/bi00610a012. [DOI] [PubMed] [Google Scholar]
  14. Hilz H., Stone P. Poly(ADP-ribose) and ADP-ribosylation of proteins. Rev Physiol Biochem Pharmacol. 1976;76:1-58, 177. doi: 10.1007/BFb0027686. [DOI] [PubMed] [Google Scholar]
  15. Hori T. High incidence of sister chromatid exchanges and chromatid interchanges in the conditions of lowered activity of poly(ADP-ribose)polymerase. Biochem Biophys Res Commun. 1981 Sep 16;102(1):38–45. doi: 10.1016/0006-291x(81)91485-6. [DOI] [PubMed] [Google Scholar]
  16. James M. R., Lehmann A. R. Role of poly(adenosine diphosphate ribose) in deoxyribonucleic acid repair in human fibroblasts. Biochemistry. 1982 Aug 17;21(17):4007–4013. doi: 10.1021/bi00260a016. [DOI] [PubMed] [Google Scholar]
  17. Jaspers N. G., de Wit J., Regulski M. R., Bootsma D. Abnormal regulation of DNA replication and increased lethality in ataxia telangiectasia cells exposed to carcinogenic agents. Cancer Res. 1982 Jan;42(1):335–341. [PubMed] [Google Scholar]
  18. Jump D. B., Butt T. R., Smulson M. Nuclear protein modification and chromatin substructure. 3. Relationship between poly(adenosine diphosphate) ribosylation and different functional forms of chromatin. Biochemistry. 1979 Mar 20;18(6):983–990. doi: 10.1021/bi00573a008. [DOI] [PubMed] [Google Scholar]
  19. Miwa M., Kanai M., Kondo T., Hoshino H., Ishihara K., Sugimura T. Inhibitors of poly(ADP-ribose) polymerase enhance unscheduled DNA synthesis in human peripheral lymphocytes. Biochem Biophys Res Commun. 1981 May 15;100(1):463–470. doi: 10.1016/s0006-291x(81)80119-2. [DOI] [PubMed] [Google Scholar]
  20. Natarajan A. T., Csukás I., van Zeeland A. A. Contribution of incorporated 5-bromodeoxyuridine in DNA to the frequencies of sister-chromatid exchanges induced by inhibitors of poly-(ADP-ribose)-polymerase. Mutat Res. 1981 Nov;84(1):125–132. doi: 10.1016/0027-5107(81)90056-7. [DOI] [PubMed] [Google Scholar]
  21. Nduka N., Skidmore C. J., Shall S. The enhancement of cytotoxicity of N-methyl-N-nitrosourea and of gamma-radiation by inhibitors of poly(ADP-ribose) polymerase. Eur J Biochem. 1980 Apr;105(3):525–530. doi: 10.1111/j.1432-1033.1980.tb04528.x. [DOI] [PubMed] [Google Scholar]
  22. Oikawa A., Tohda H., Kanai M., Miwa M., Sugimura T. Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges. Biochem Biophys Res Commun. 1980 Dec 31;97(4):1311–1316. doi: 10.1016/s0006-291x(80)80009-x. [DOI] [PubMed] [Google Scholar]
  23. Purnell M. R., Stone P. R., Whish W. J. ADP-ribosylation of nuclear proteins. Biochem Soc Trans. 1980 Apr;8(2):215–227. doi: 10.1042/bst0080215. [DOI] [PubMed] [Google Scholar]
  24. Waters R., Ramsay F., Barrett I. 3-Aminobenzamide, an inhibitor of poly ADP-ribose polymerase, decreases the frequency of alkaline labile lesions and increases growth in human fibroblasts exposed to 3-methyl 4-nitroquinoline 1-oxide. Carcinogenesis. 1982;3(12):1463–1467. doi: 10.1093/carcin/3.12.1463. [DOI] [PubMed] [Google Scholar]
  25. Yamada M., Nagao M., Miwa M., Sugimura T. Inhibition of deoxyribonuclease in an extract of rat liver nuclei by poly(ADP-ribose). Biochem Biophys Res Commun. 1974 Feb 27;56(4):1093–1099. doi: 10.1016/s0006-291x(74)80300-1. [DOI] [PubMed] [Google Scholar]
  26. Yoshihara K., Tanigawa Y., Burzio L., Koide S. S. Evidence for adenosine diphosphate ribosylation of Ca2+, Mg2+-dependent endonuclease. Proc Natl Acad Sci U S A. 1975 Jan;72(1):289–293. doi: 10.1073/pnas.72.1.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Zwelling L. A., Kerrigan D., Mattern M. R. Ataxia-telangiectasia cells are not uniformly deficient in poly(ADP-ribose) synthesis following X-irradiation. Mutat Res. 1983 Apr;120(1):69–78. doi: 10.1016/0165-7992(83)90076-3. [DOI] [PubMed] [Google Scholar]
  28. Zwelling L. A., Kerrigan D., Pommier Y. Inhibitors of poly-(adenosine diphosphoribose) synthesis slow the resealing rate of x-ray-induced DNA strand breaks. Biochem Biophys Res Commun. 1982 Feb 11;104(3):897–902. doi: 10.1016/0006-291x(82)91333-x. [DOI] [PubMed] [Google Scholar]
  29. Zwelling L. A., Kerrigan D., Pommier Y., Michaels S., Steren A., Kohn K. W. Formation and resealing of intercalator-induced DNA strand breaks in permeabilized L1210 cells without the stimulated synthesis of poly(ADP-ribose). J Biol Chem. 1982 Aug 10;257(15):8957–8963. [PubMed] [Google Scholar]

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