Abstract
The shape of cell survival curves following X-irradiation when the X-rays were given immediately after neutron irradiation has been examined in two cell lines in vitro (Ehrlich ascites and V79) and in the stem cells of the mouse jejunum. The changes in the shape of the X-ray survival curve following neutron irradiation are different in all the cell systems examined. Some of the changes observed may be associated with a change in the cell profile following neutron irradiation due to the more even cell age killing pattern of neutrons through the cell cycle compared with X-rays. It is unlikely that this can account for all changes in shape observed and it is postulated that some cells following neutron irradiation are more sensitive to X-rays than the unirradiated population or than X-irradiated cells at the same level of survival. This increased sensitivity may be associated with a non-reversible sublethal damage or a saturation of the repair potential caused largely by the alpha or heavy recoil (HR) particles produced by the neutrons in the cell nucleus. The damage is observed when the probability of alpha or HR particles being produced within the cell nucleus, without killing the cell, is high.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bewley D. K., McNally N. J., Page B. C. Effect of the secondary charged-particle spectrum on cellular response to fast neutrons. Radiat Res. 1974 Apr;58(1):111–121. [PubMed] [Google Scholar]
- Durand R. E., Olive P. L. Irradiation of multi-cell spheroids with fast neutrons versus X-rays: a qualitative difference in sub-lethal damage repair capacity or kinetics. Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Dec;30(6):589–592. doi: 10.1080/09553007614551481. [DOI] [PubMed] [Google Scholar]
- Hall E. J., Bird R. P., Rossi H. H., Coffey R., Varga J., Lam Y. M. Biophysical studies with high-energy argon ions 2. Determinations of the relative biological effectiveness, the oxygen enhancement ratio, and the cell cycle response. Radiat Res. 1977 Jun;70(3):469–479. [PubMed] [Google Scholar]
- Higgins P. D., DeLuca P. M., Jr, Pearson D. W., Gould M. N. V79 survival following simultaneous or sequential irradiation by 15-MeV neutrons and 60Co photons. Radiat Res. 1983 Jul;95(1):45–56. [PubMed] [Google Scholar]
- Hornsey S., Andreozzi U., Warren P. R. Sublethal damage in cells of the mouse gut after mixed treatment with X rays and fast neutrons. Br J Radiol. 1977 Jul;50(595):513–517. doi: 10.1259/0007-1285-50-595-513. [DOI] [PubMed] [Google Scholar]
- Lloyd E. L., Gemmell M. A., Henning C. B., Gemmell D. S., Zabransky B. J. Cell survival following multiple-track alpha particle irradiation. Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Jan;35(1):23–31. doi: 10.1080/09553007914550031. [DOI] [PubMed] [Google Scholar]
- Masuda K. Effects of 14 MeV neutrons and x-rays, singly or combined on the reproductive capacity of L cells. J Radiat Res. 1970 Sep-Dec;11(3):107–112. doi: 10.1269/jrr.11.107. [DOI] [PubMed] [Google Scholar]
- Ngo F. Q., Blakely E. A., Tobias C. A. Sequential exposures of mammalian cells to low- and high-LET radiations. I. Lethal effects following X-ray and neon-ion irradiation. Radiat Res. 1981 Jul;87(1):59–78. [PubMed] [Google Scholar]
- Ngo F. Q., Han A., Elkind M. M. On the repair of sub-lethal damage in V79 Chinease hamster cells resulting from irradiation with fast neutrons or fast neutrons combined with X-rays. Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Nov;32(5):507–511. doi: 10.1080/09553007714551291. [DOI] [PubMed] [Google Scholar]
- Railton R., Lawson R. C., Porter D. Interaction of gamma-ray and neutron effects on the proliferative capacity of Chinese hamster cells. Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Jan;27(1):75–82. doi: 10.1080/09553007514550071. [DOI] [PubMed] [Google Scholar]
- Raju M. R., Bain E., Carpenter S. G., Jett J., Walters R. A., Howard J., Powers-Risius P. Effects of argon ions on synchronized Chinese hamster cells. Radiat Res. 1980 Oct;84(1):152–157. [PubMed] [Google Scholar]