Abstract
Cis-dichlorodiammineplatinum (II), or cis-PDD, has recently been shown to be a potent radiosensitizer of bacteria, particularly under conditions of acute hypoxia. This study extends this observation to include the radiosensitization of mammalian cell (V-79) by low concentrations of cis-PDD, cis-dichlorobis(aziridine) platinum (II), and the trans-isomer of PDD as measured from survival curve analysis. This radiosensitization was obtained at concentrations of 10 micrometer, 60 micrometer, and 100 micrometer for the cis-PDD, aziridine-platinum, and trans-isomer respectively. The corresponding drug toxicity survival levels were 8, 40 and 50%. Dose modification factors of around 1.3 to 1.4 were observed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chadwick K. H., Leenhouts H. P., Szumiel I., Nias A. H. An analysis of the interaction of a platinum complex and radiation with CHO cells using the molecular theory of cell survival. Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Dec;30(6):511–524. doi: 10.1080/09553007614551371. [DOI] [PubMed] [Google Scholar]
- Connors T. A., Jones M., Ross W. C., Braddock P. D., Khokhar A. R., Tobe M. L. New platinum complexes with anti-tumour activity. Chem Biol Interact. 1972 Nov;5(6):415–424. doi: 10.1016/0009-2797(72)90078-6. [DOI] [PubMed] [Google Scholar]
- Koch C. J., Kruuv J. The effect of extreme hypoxia on recovery after radiation by synchronized mammalian cells. Radiat Res. 1971 Oct;48(1):74–85. [PubMed] [Google Scholar]
- Richmond R. C., Powers E. L. Radiation sensitization of bacterial spores by cis-dichlorodiammineplatinum(II). Radiat Res. 1976 Nov;68(2):251–257. [PubMed] [Google Scholar]
- Richmond R. C., Zimbrick J. D., Hykes D. L. Radiation-induced DNA damage and lethality in E. coli as modified by the antitumor agent cis-dichlorodiammineplatinum (II). Radiat Res. 1977 Aug;71(2):447–460. [PubMed] [Google Scholar]
- Rosenberg B. Platinum coordination complexes in cancer chemotherapy. Naturwissenschaften. 1973 Sep;60(9):399–406. doi: 10.1007/BF00623551. [DOI] [PubMed] [Google Scholar]
- Szumiel I., Nias A. H. The effect of combined treatment with a platinum complex and ionizing radiation on chinese hamster ovary cells in vitro. Br J Cancer. 1976 Apr;33(4):450–458. doi: 10.1038/bjc.1976.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wodinsky I., Swiniarski J., Kensler C. J., Venditti J. M. Combination radiotherapy and chemotherapy for P388 lymphocytic leukemia in vivo. Cancer Chemother Rep 2. 1974 Mar;4(1):73–97. [PubMed] [Google Scholar]