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. 1975 Mar;2:456–464.

Clinical trials in the non-Hodgkin's lymphomata at Stanford University experimental design and preliminary results.

S A Rosenberg, H S Kaplan
PMCID: PMC2149597  PMID: 1101931

Abstract

Preliminary results of controlled clinical trials in 127 patients with non-Hodgkin's lymphomata are reported. The rationale for identifying 7 study groups is presented. Treatment programmes which are being studied vary from involved field irradiation to the most aggressive treatment tolerable. The early results suggest that patients with both favourable and unfavourable histologies but of limited extent can be controlled with irradiation. Patients with advanced disease but with favourable histological subgroups are doing as well with a conservative drug programme as with 2 aggressive treatment regimens. These controlled studies and those of others, facilitated by the use of the Rappaport classification and laparotomy staging, give promise of clarifying and improving the management of patients with these lymphomata.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bagley C. M., Jr, Devita V. T., Jr, Berard C. W., Canellos G. P. Advanced lymphosarcoma: intensive cyclical combination chemotherapy with cyclophosphamide, vincristine, and prednisone. Ann Intern Med. 1972 Feb;76(2):227–234. doi: 10.7326/0003-4819-76-2-227. [DOI] [PubMed] [Google Scholar]
  2. Bonadonna G., Monfardini S., De Lena M., Fossati-Bellani F. Clinical evaluation of adriamycin, a new antitumour antibiotic. Br Med J. 1969 Aug 30;3(5669):503–506. doi: 10.1136/bmj.3.5669.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carbone P. P., Kaplan H. S., Musshoff K., Smithers D. W., Tubiana M. Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res. 1971 Nov;31(11):1860–1861. [PubMed] [Google Scholar]
  4. GEHAN E. A. A GENERALIZED WILCOXON TEST FOR COMPARING ARBITRARILY SINGLY-CENSORED SAMPLES. Biometrika. 1965 Jun;52:203–223. [PubMed] [Google Scholar]
  5. Glatstein E., Trueblood H. W., Enright L. P., Rosenberg S. A., Kaplan H. S. Surgical staging of abdominal involvement in unselected patients with Hodgkin's disease. Radiology. 1970 Nov;97(2):425–432. doi: 10.1148/97.2.425. [DOI] [PubMed] [Google Scholar]
  6. Goffinet D. R., Castellino R. A., Kim H., Dorfman R. F., Fuks Z., Rosenberg S. A., Nelsen T., Kaplan H. S. Staging laparotomies in unselected previously untreated patients with non-Hodgkin's lymphomas. Cancer. 1973 Sep;32(3):672–681. doi: 10.1002/1097-0142(197309)32:3<672::aid-cncr2820320321>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  7. HICKS E. B., RAPPAPORT H., WINTER W. J. Follicular lymphoma; a re-evaluation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases. Cancer. 1956 Jul-Aug;9(4):792–821. doi: 10.1002/1097-0142(195607/08)9:4<792::aid-cncr2820090429>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  8. Jones S. E., Fuks Z., Bull M., Kadin M. E., Dorfman R. F., Kaplan H. S., Rosenberg S. A., Kim H. Non-Hodgkin's lymphomas. IV. Clinicopathologic correlation in 405 cases. Cancer. 1973 Apr;31(4):806–823. doi: 10.1002/1097-0142(197304)31:4<806::aid-cncr2820310408>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  9. Jones S. E., Kaplan H. S., Rosenberg S. A. Non-Hodgkin's lymphomas. 3. Preliminary results of radiotherapy and a proposal for new clinical trials. Radiology. 1972 Jun;103(3):657–662. doi: 10.1148/103.3.657. [DOI] [PubMed] [Google Scholar]
  10. Kaplan H. S., Rosenberg S. A. International Symposium on Hodgkin's Disease. Session 5. Treatment. Current status of clinical trials: Stanford experience, 1962-72. Natl Cancer Inst Monogr. 1973 May;36:363–371. [PubMed] [Google Scholar]
  11. Rosenberg S. A. Bone marrow involvement in the non-Hodgkin's lymphomata. Br J Cancer Suppl. 1975 Mar;2:261–264. [PMC free article] [PubMed] [Google Scholar]
  12. Rosenberg S. A., Dorfman R. F., Kaplan H. S. The value of sequential bone marrow biopsy and laparotomy and splenectomy in a series of 127 consecutive untreated patients with non-Hodgkin's lymphoma. Br J Cancer Suppl. 1975 Mar;2:221–227. [PMC free article] [PubMed] [Google Scholar]
  13. Rosenberg S. A., Kaplan H. S. Hodgkin's disease and other malignant lymphomas. Calif Med. 1970 Oct;113(4):23–38. [PMC free article] [PubMed] [Google Scholar]
  14. Rosenberg S. A., Moore M. R., Bull J. M., Jones S. E., Kaplan H. S. Combination chemotherapy and radiotherapy for Hodgkin's disease. Cancer. 1972 Dec;30(6):1505–1510. doi: 10.1002/1097-0142(197212)30:6<1505::aid-cncr2820300614>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]

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