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. 1992 Aug;18:S20–S22.

Cytogenetic findings in acute leukaemias of infants.

F Lampert 1, J Harbott 1, J Ritterbach 1
PMCID: PMC2149651  PMID: 1503922

Abstract

Of 706 children, 528 with acute lymphoblastic leukaemia (ALL) and 178 with acute myelocytic leukaemia (AML), whose leukaemia karyotypes could be successfully analysed, 48 were infants less than 1 year of age, 28 with ALL (5% of ALL patients) and 20 with AML (11% of AML patients). In contrast to older children. ALL-leukaemocytogenetics in infants was characterised by lack of hyperdiploidy with over 50 chromosomes and higher incidence of pseudodiploidy. Thirteen (= 46%) infants had an 11q23 aberration, and 11 of them had t(4;11). In AML, nine (= 45%) infants also had an 11q23 abnormality, e.g. t(9;11). Thus, the 11q23 aberration was present in almost 50% of all leukaemia karyotypes of infants. In ALL of infants, the CALLA negative, pre-pre-B immunophenotype prevailed. In AML of infants, the monocytic subtype dominated. A biphenotypic morphology (lymphoid-monocytic) with the expression of lymphoid and myeloid antigens was seen in several ALL and AML cases. In conclusion, leukaemogenesis in infants is a rare event, arising in stem cells of very early hematopoietic differentiation (probably due to gene rearrangement errors, most frequently at FRA11B), and differs from leukaemogenesis in older age groups by unique clinical and cellular features.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bhat N. K., Thompson C. B., Lindsten T., June C. H., Fujiwara S., Koizumi S., Fisher R. J., Papas T. S. Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1. Proc Natl Acad Sci U S A. 1990 May;87(10):3723–3727. doi: 10.1073/pnas.87.10.3723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gibbons B., Katz F. E., Ganly P., Chessells J. M. Infant acute lymphoblastic leukaemia with t(11; 19). Br J Haematol. 1990 Mar;74(3):264–269. doi: 10.1111/j.1365-2141.1990.tb02581.x. [DOI] [PubMed] [Google Scholar]
  3. Huebner K., Nowell P. C., Croce C. M. Lineage-specific gene rearrangement/deletion: a nonconservative model. Cancer Res. 1989 Aug 1;49(15):4071–4074. [PubMed] [Google Scholar]
  4. Kaneko Y., Shikano T., Maseki N., Sakurai M., Sakurai M., Takeda T., Hiyoshi Y., Mimaya J., Fujimoto T. Clinical characteristics of infant acute leukemia with or without 11q23 translocations. Leukemia. 1988 Oct;2(10):672–676. [PubMed] [Google Scholar]
  5. Köller U., Haas O. A., Ludwig W. D., Bartram C. R., Harbott J., Panzer-Grümayer R., Hansen-Hagge T., Ritter J., Creutzig U., Knapp W. Phenotypic and genotypic heterogeneity in infant acute leukemia. II. Acute nonlymphoblastic leukemia. Leukemia. 1989 Oct;3(10):708–714. [PubMed] [Google Scholar]
  6. Lampert F., Harbott J., Ludwig W. D., Bartram C. R., Ritter J., Gerein V., Neidhardt M., Mertens R., Graf N., Riehm H. Acute leukemia with chromosome translocation (4;11): 7 new patients and analysis of 71 cases. Blut. 1987 Jun;54(6):325–335. doi: 10.1007/BF00626012. [DOI] [PubMed] [Google Scholar]
  7. Ludwig W. D., Bartram C. R., Harbott J., Köller U., Haas O. A., Hansen-Hagge T., Heil G., Seibt-Jung H., Teichmann J. V., Ritter J. Phenotypic and genotypic heterogeneity in infant acute leukemia. I. Acute lymphoblastic leukemia. Leukemia. 1989 Jun;3(6):431–439. [PubMed] [Google Scholar]
  8. Pui C. H., Raimondi S. C., Murphy S. B., Ribeiro R. C., Kalwinsky D. K., Dahl G. V., Crist W. M., Williams D. L. An analysis of leukemic cell chromosomal features in infants. Blood. 1987 May;69(5):1289–1293. [PubMed] [Google Scholar]
  9. Sait S. N., Brecher M. L., Green D. M., Sandberg A. A. Translocation t(1;22) in congenital acute megakaryocytic leukemia. Cancer Genet Cytogenet. 1988 Sep;34(2):277–280. doi: 10.1016/0165-4608(88)90273-7. [DOI] [PubMed] [Google Scholar]
  10. Stark B., Vogel R., Cohen I. J., Umiel T., Mammon Z., Rechavi G., Kaplinsky C., Potaznik D., Dvir A., Yaniv Y. Biologic and cytogenetic characteristics of leukemia in infants. Cancer. 1989 Jan 1;63(1):117–125. doi: 10.1002/1097-0142(19890101)63:1<117::aid-cncr2820630119>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  11. van Wering E. R., Kamps W. A. Acute leukemia in infants. A unique pattern of acute nonlymphocytic leukemia. Am J Pediatr Hematol Oncol. 1986 Fall;8(3):220–224. doi: 10.1097/00043426-198623000-00008. [DOI] [PubMed] [Google Scholar]

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