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The British Journal of Cancer. Supplement logoLink to The British Journal of Cancer. Supplement
. 1992 Aug;18:S72–S75.

Spontaneous regression of neonatal fibrosarcoma.

N P Madden 1, R D Spicer 1, E B Allibone 1, I J Lewis 1
PMCID: PMC2149666  PMID: 1503930

Abstract

We report a case of fibrosarcoma, which presented in a two week old boy. Excision was not performed because it would have required mutilating surgery. The tumour regressed and was impalpable by 7 months of age. The patient is tumour free at 4 years of age. This is the first reported case of spontaneous regression of a fibrosarcoma. The literature is reviewed. We conclude that the chances of metastasis are low, tumours are likely to respond to chemotherapy, and mutilating surgery is not appropriate initial treatment for infantile fibrosarcomas.

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Selected References

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  1. Balsaver A. M., Butler J. J., Martin R. G. Congenital fibrosarcoma. Cancer. 1967 Oct;20(10):1607–1616. doi: 10.1002/1097-0142(196710)20:10<1607::aid-cncr2820201007>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  2. Bernadó L., Admella C., Lucaya J., Sanchez de Toledo J., Bosch J. Infantile fibrosarcoma of femur. Pediatr Pathol. 1987;7(2):201–207. doi: 10.1080/15513818709177843. [DOI] [PubMed] [Google Scholar]
  3. Blocker S., Koenig J., Ternberg J. Congenital fibrosarcoma. J Pediatr Surg. 1987 Jul;22(7):665–670. doi: 10.1016/s0022-3468(87)80123-9. [DOI] [PubMed] [Google Scholar]
  4. Chung E. B., Enzinger F. M. Infantile fibrosarcoma. Cancer. 1976 Aug;38(2):729–739. doi: 10.1002/1097-0142(197608)38:2<729::aid-cncr2820380216>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  5. Delepine N., Cornille H., Desbois J. C., Delepine G., Voisin M. C. Complete response of congenital fibrosarcoma to chemotherapy. Lancet. 1986 Dec 20;2(8521-22):1453–1454. doi: 10.1016/s0140-6736(86)92755-8. [DOI] [PubMed] [Google Scholar]
  6. Drut R. Congenital fibrosarcoma: a congenital fibrous histiocytoma. Pediatr Pathol. 1986;6(4):403–409. doi: 10.3109/15513818609041555. [DOI] [PubMed] [Google Scholar]
  7. GOSLEE L., CLERMONT V., BERNSTEIN J., WOOLLEY P. V., Jr SUPERFICIAL CONNECTIVE TISSUE TUMORS IN EARLY INFANCY: A STUDY OF FIBROMATOSIS AND LIPOBLASTOMATOSIS. J Pediatr. 1964 Sep;65:377–387. doi: 10.1016/s0022-3476(64)80402-9. [DOI] [PubMed] [Google Scholar]
  8. Gonzalez-Crussi F., Wiederhold M. D., Sotelo-Avila C. Congenital fibrosarcoma: presence of a histiocytic component. Cancer. 1980 Jul 1;46(1):77–86. doi: 10.1002/1097-0142(19800701)46:1<77::aid-cncr2820460116>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  9. Grier H. E., Perez-Atayde A. R., Weinstein H. J. Chemotherapy for inoperable infantile fibrosarcoma. Cancer. 1985 Oct 1;56(7):1507–1510. doi: 10.1002/1097-0142(19851001)56:7<1507::aid-cncr2820560705>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  10. Hays D. M., Mirabal V. Q., Karlan M. S., Patel H. R., Landing B. H. Fibrosarcomas in infants and children. J Pediatr Surg. 1970 Apr;5(2):176–183. doi: 10.1016/0022-3468(70)90274-5. [DOI] [PubMed] [Google Scholar]
  11. Iwasaki H., Enjoji M. Infantile and adult fibrosarcomas of the soft tissues. Acta Pathol Jpn. 1979 May;29(3):377–388. doi: 10.1111/j.1440-1827.1979.tb00195.x. [DOI] [PubMed] [Google Scholar]
  12. Mandahl N., Heim S., Rydholm A., Willen H., Mitelman F. Nonrandom numerical chromosome aberrations (+8, +11, +17, +20) in infantile fibrosarcoma. Cancer Genet Cytogenet. 1989 Jul 1;40(1):137–139. doi: 10.1016/0165-4608(89)90156-8. [DOI] [PubMed] [Google Scholar]
  13. Mitrofanoff P., Vannier J. P., Bachy B., Hemet J., Boillot B., Borde J. Fibromatoses de l'enfant: régression sous chimiothérapie prolongée. A propos de 2 cas. Chir Pediatr. 1988;29(6):325–329. [PubMed] [Google Scholar]
  14. Ninane J., Gosseye S., Panteon E., Claus D., Rombouts J. J., Cornu G. Congenital fibrosarcoma. Preoperative chemotherapy and conservative surgery. Cancer. 1986 Oct 1;58(7):1400–1406. doi: 10.1002/1097-0142(19861001)58:7<1400::aid-cncr2820580703>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  15. STOUT A. P. Fibrosarcoma in infants and children. Cancer. 1962 Sep-Oct;15:1028–1040. doi: 10.1002/1097-0142(196209/10)15:5<1028::aid-cncr2820150520>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  16. STOUT A. P. Juvenile fibromatoses. Cancer. 1954 Sep;7(5):953–978. doi: 10.1002/1097-0142(195409)7:5<953::aid-cncr2820070520>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  17. Siegal A., Horowitz A. Aggressive fibromatosis (infantile fibrosarcoma). Difficulty of diagnostic and prognostic evaluation. Clin Pediatr (Phila) 1978 Jun;17(6):517–520. doi: 10.1177/000992287801700613. [DOI] [PubMed] [Google Scholar]
  18. Sinclair-Smith C. C., Emms M., Mills A. E. Intracisternal paracrystalline serpigenous inclusions: a marker of disordered fibroblastic proliferation. Ultrastruct Pathol. 1989 Jul-Aug;13(4):443–449. doi: 10.3109/01913128909048494. [DOI] [PubMed] [Google Scholar]
  19. Soule E. H., Pritchard D. J. Fibrosarcoma in infants and children: a review of 110 cases. Cancer. 1977 Oct;40(4):1711–1721. doi: 10.1002/1097-0142(197710)40:4<1711::aid-cncr2820400447>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  20. Speleman F., Dal Cin P., De Potter K., Laureys G., Roels H. J., Leroy J., Van Den Berghe H. Cytogenetic investigation of a case of congenital fibrosarcoma. Cancer Genet Cytogenet. 1989 May;39(1):21–24. doi: 10.1016/0165-4608(89)90224-0. [DOI] [PubMed] [Google Scholar]
  21. Sulamaa M., Möller C. Soft tissue sarcoma in children. J Pediatr Surg. 1969 Oct;4(5):520–525. doi: 10.1016/0022-3468(69)90091-8. [DOI] [PubMed] [Google Scholar]
  22. Wee A., Pho R. W., Ong L. B. Infantile fibrosarcoma: report of cases. Arch Pathol Lab Med. 1979 May;103(5):236–238. [PubMed] [Google Scholar]

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