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. 1992 Aug;18:S54–S57.

Leukaemia in the young child.

J M Chessells 1
PMCID: PMC2149669  PMID: 1503927

Abstract

Leukaemia is rare in infancy with an equal predominance of lymphoblastic and myeloblastic cases. Acute lymphoblastic leukaemia in infants under one year is characterised by a high leucocyte count, organomegaly, early B-cell phenotype, sometimes with evidence of monocytoid differentiation and cytogenetic abnormalities. This is reflected in its poor prognosis. The toddler (aged 1-2) tends to develop typical childhood ALL which is responsive to treatment, but remains vulnerable to late effects of therapy, particularly radiation. The distribution of subtypes of AML differs in the younger and older child and results of treatment have improved in all age groups. A uniform strategy appears desirable for all cases of childhood AML. It seems probable that different genetic and environmental factors may be involved in the genesis of infant ALL, childhood ALL and AML in children. The management of leukaemia in children under two poses a considerable challenge.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A., Gralnick H. R., Sultan C. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group. Ann Intern Med. 1985 Sep;103(3):460–462. doi: 10.7326/0003-4819-103-3-460. [DOI] [PubMed] [Google Scholar]
  2. Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A., Gralnick H. R., Sultan C. The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations. Br J Haematol. 1981 Apr;47(4):553–561. doi: 10.1111/j.1365-2141.1981.tb02684.x. [DOI] [PubMed] [Google Scholar]
  3. Chessells J. M., Cox T. C., Kendall B., Cavanagh N. P., Jannoun L., Richards S. Neurotoxicity in lymphoblastic leukaemia: comparison of oral and intramuscular methotrexate and two doses of radiation. Arch Dis Child. 1990 Apr;65(4):416–422. doi: 10.1136/adc.65.4.416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chessells J. M., Leiper A. D., Tiedemann K., Hardisty R. M., Richards S. Oral methotrexate is as effective as intramuscular in maintenance therapy of acute lymphoblastic leukaemia. Arch Dis Child. 1987 Feb;62(2):172–176. doi: 10.1136/adc.62.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chessells J. M., O'Callaghan U., Hardisty R. M. Acute myeloid leukaemia in childhood: clinical features and prognosis. Br J Haematol. 1986 Jul;63(3):555–564. doi: 10.1111/j.1365-2141.1986.tb07533.x. [DOI] [PubMed] [Google Scholar]
  6. Crist W., Pullen J., Boyett J., Falletta J., van Eys J., Borowitz M., Jackson J., Dowell B., Frankel L., Quddus F. Clinical and biologic features predict a poor prognosis in acute lymphoid leukemias in infants: a Pediatric Oncology Group Study. Blood. 1986 Jan;67(1):135–140. [PubMed] [Google Scholar]
  7. Kalwinsky D. K., Raimondi S. C., Schell M. J., Mirro J., Jr, Santana V. M., Behm F., Dahl G. V., Williams D. Prognostic importance of cytogenetic subgroups in de novo pediatric acute nonlymphocytic leukemia. J Clin Oncol. 1990 Jan;8(1):75–83. doi: 10.1200/JCO.1990.8.1.75. [DOI] [PubMed] [Google Scholar]
  8. Katz F., Malcolm S., Gibbons B., Tilly R., Lam G., Robertson M. E., Czepulkowski B., Chessells J. Cellular and molecular studies on infant null acute lymphoblastic leukemia. Blood. 1988 May;71(5):1438–1447. [PubMed] [Google Scholar]
  9. Leiper A. D., Chessells J. Acute lymphoblastic leukaemia under 2 years. Arch Dis Child. 1986 Oct;61(10):1007–1012. doi: 10.1136/adc.61.10.1007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Leiper A. D., Stanhope R., Kitching P., Chessells J. M. Precocious and premature puberty associated with treatment of acute lymphoblastic leukaemia. Arch Dis Child. 1987 Nov;62(11):1107–1112. doi: 10.1136/adc.62.11.1107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lithotripsy. Health and Public Policy Committee, American College of Physicians. Ann Intern Med. 1985 Oct;103(4):626–629. [PubMed] [Google Scholar]
  12. Phillips M., Richards S., Chessells J. Acute myeloid leukaemia in childhood: the costs and benefits of intensive treatment. Br J Haematol. 1991 Apr;77(4):473–477. doi: 10.1111/j.1365-2141.1991.tb08612.x. [DOI] [PubMed] [Google Scholar]
  13. Pinkerton C. R., Bowman A., Holtzel H., Chessells J. M. Intensive consolidation chemotherapy for acute lymphoblastic leukaemia (UKALL X pilot study). Arch Dis Child. 1987 Jan;62(1):12–18. doi: 10.1136/adc.62.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Reaman G., Zeltzer P., Bleyer W. A., Amendola B., Level C., Sather H., Hammond D. Acute lymphoblastic leukemia in infants less than one year of age: a cumulative experience of the Children's Cancer Study Group. J Clin Oncol. 1985 Nov;3(11):1513–1521. doi: 10.1200/JCO.1985.3.11.1513. [DOI] [PubMed] [Google Scholar]
  15. Stiller C. A. Descriptive epidemiology of childhood leukaemia and lymphoma in Great Britain. Leuk Res. 1985;9(6):671–674. doi: 10.1016/0145-2126(85)90273-5. [DOI] [PubMed] [Google Scholar]

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