Abstract
The effective management of advanced colorectal cancer has traditionally been viewed in terms of treatment outcome measures such as efficacy (survival, objective response and palliation) and safety. Although these outcomes are of paramount importance and are essential for the evaluation of the effectiveness and tolerability of treatment, they do not take account of the global effect of therapy on patients, society and healthcare systems. Furthermore, they may not reveal important differences between treatments of equivalent anti-tumour efficacy that might influence the overall effectiveness in terms of acceptability of therapy. To achieve this, a broader, patient-centred evaluation of advanced cancer treatment is required that acknowledges the views, experience and perspectives of all involved in the treatment process. To this end, the International Working Group in Colorectal Cancer, a multidisciplinary group that encompasses expertise from a range of relevant fields and disciplines, has advocated a multidisciplinary approach to the treatment of advanced colorectal cancer that is likely to deliver the best possible overall care.
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- Domergue J., Rouanet P., Daures J. P., Kasse A., Dubois J. B., Joyeux H., Solassol C., Pujol H. Cancer du rectum: traitement par association radio-chirurgicale de 328 malades. Etude mono- et multifactorielle des facteurs de pronostic. Gastroenterol Clin Biol. 1988 Nov;12(11):797–802. [PubMed] [Google Scholar]
- Donovan K., Sanson-Fisher R. W., Redman S. Measuring quality of life in cancer patients. J Clin Oncol. 1989 Jul;7(7):959–968. doi: 10.1200/JCO.1989.7.7.959. [DOI] [PubMed] [Google Scholar]
- Douglass H. O., Jr, Moertel C. G., Mayer R. J., Thomas P. R., Lindblad A. S., Mittleman A., Stablein D. M., Bruckner H. W. Survival after postoperative combination treatment of rectal cancer. N Engl J Med. 1986 Nov 13;315(20):1294–1295. doi: 10.1056/NEJM198611133152014. [DOI] [PubMed] [Google Scholar]
- Glimelius B., Hoffman K., Graf W., Haglund U., Nyrén O., Påhlman L., Sjödén P. O. Cost-effectiveness of palliative chemotherapy in advanced gastrointestinal cancer. Ann Oncol. 1995 Mar;6(3):267–274. doi: 10.1093/oxfordjournals.annonc.a059157. [DOI] [PubMed] [Google Scholar]
- Grann A., Minsky B. D., Cohen A. M., Saltz L., Guillem J. G., Paty P. B., Kelsen D. P., Kemeny N., Ilson D., Bass-Loeb J. Preliminary results of preoperative 5-fluorouracil, low-dose leucovorin, and concurrent radiation therapy for clinically resectable T3 rectal cancer. Dis Colon Rectum. 1997 May;40(5):515–522. doi: 10.1007/BF02055370. [DOI] [PubMed] [Google Scholar]
- Hyams D. M., Mamounas E. P., Petrelli N., Rockette H., Jones J., Wieand H. S., Deutsch M., Wickerham L., Fisher B., Wolmark N. A clinical trial to evaluate the worth of preoperative multimodality therapy in patients with operable carcinoma of the rectum: a progress report of National Surgical Breast and Bowel Project Protocol R-03. Dis Colon Rectum. 1997 Feb;40(2):131–139. doi: 10.1007/BF02054976. [DOI] [PubMed] [Google Scholar]
- Krook J. E., Moertel C. G., Gunderson L. L., Wieand H. S., Collins R. T., Beart R. W., Kubista T. P., Poon M. A., Meyers W. C., Mailliard J. A. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med. 1991 Mar 14;324(11):709–715. doi: 10.1056/NEJM199103143241101. [DOI] [PubMed] [Google Scholar]
- Leo E., Belli F., Baldini M. T., Vitellaro M., Santoro N., Mascheroni L., Andreola S., Bellomi M., Rebuffoni G., Zucali R. Total rectal resection, colo-endoanal anastomosis and colic reservoir for cancer of the lower third of the rectum. Eur J Surg Oncol. 1993 Jun;19(3):283–293. [PubMed] [Google Scholar]
- McAnena O. J., Heald R. J., Lockhart-Mummery H. E. Operative and functional results of total mesorectal excision with ultra-low anterior resection in the management of carcinoma of the lower one-third of the rectum. Surg Gynecol Obstet. 1990 Jun;170(6):517–521. [PubMed] [Google Scholar]
- Minsky B. D., Cohen A. M., Enker W. E., Kelsen D. P., Kemeny N., Riechman B., Saltz L., Sigurdson E. R., Frankel J. Phase I trial of postoperative 5-FU, radiation therapy, and high dose leucovorin for resectable rectal cancer. Int J Radiat Oncol Biol Phys. 1992;22(1):139–145. doi: 10.1016/0360-3016(92)90993-r. [DOI] [PubMed] [Google Scholar]
- Minsky B. D., Cohen A. M., Kemeny N., Enker W. E., Kelsen D. P., Reichman B., Saltz L., Sigurdson E. R., Frankel J. Combined modality therapy of rectal cancer: decreased acute toxicity with the preoperative approach. J Clin Oncol. 1992 Aug;10(8):1218–1224. doi: 10.1200/JCO.1992.10.8.1218. [DOI] [PubMed] [Google Scholar]
- Minsky B. D., Kemeny N., Cohen A. M., Enker W. E., Kelsen D. P., Reichman B., Saltz L., Sigurdson E. R., Frankel J. Preoperative high-dose leucovorin/5-fluorouracil and radiation therapy for unresectable rectal cancer. Cancer. 1991 Jun 1;67(11):2859–2866. doi: 10.1002/1097-0142(19910601)67:11<2859::aid-cncr2820671126>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
- Moinpour C. M., Feigl P., Metch B., Hayden K. A., Meyskens F. L., Jr, Crowley J. Quality of life end points in cancer clinical trials: review and recommendations. J Natl Cancer Inst. 1989 Apr 5;81(7):485–495. doi: 10.1093/jnci/81.7.485. [DOI] [PubMed] [Google Scholar]
- Palmer K. R., Kerr M., Knowles G., Cull A., Carter D. C., Leonard R. C. Chemotherapy prolongs survival in inoperable pancreatic carcinoma. Br J Surg. 1994 Jun;81(6):882–885. doi: 10.1002/bjs.1800810629. [DOI] [PubMed] [Google Scholar]
- Perez E. A., Gandara D. R. Advances in the control of chemotherapy-induced emesis. Ann Oncol. 1992 Aug;3 (Suppl 3):47–50. doi: 10.1093/annonc/3.suppl_3.s47. [DOI] [PubMed] [Google Scholar]
- Pollett W. G., Nicholls R. J. The relationship between the extent of distal clearance and survival and local recurrence rates after curative anterior resection for carcinoma of the rectum. Ann Surg. 1983 Aug;198(2):159–163. doi: 10.1097/00000658-198308000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rouanet P., Fabre J. M., Dubois J. B., Dravet F., Saint Aubert B., Pradel J., Ychou M., Solassol C., Pujol H. Conservative surgery for low rectal carcinoma after high-dose radiation. Functional and oncologic results. Ann Surg. 1995 Jan;221(1):67–73. doi: 10.1097/00000658-199501000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rouanet P., Saint Aubert B., Fabre J. M., Astre C., Liu J. Z., Dubois J. B., Joyeux H., Solassol C., Pujol H. Conservative treatment for low rectal carcinoma by local excision with or without radiotherapy. Br J Surg. 1993 Nov;80(11):1452–1456. doi: 10.1002/bjs.1800801134. [DOI] [PubMed] [Google Scholar]
- Rougier P., Laplanche A., Huguier M., Hay J. M., Ollivier J. M., Escat J., Salmon R., Julien M., Roullet Audy J. C., Gallot D. Hepatic arterial infusion of floxuridine in patients with liver metastases from colorectal carcinoma: long-term results of a prospective randomized trial. J Clin Oncol. 1992 Jul;10(7):1112–1118. doi: 10.1200/JCO.1992.10.7.1112. [DOI] [PubMed] [Google Scholar]
- Scheithauer W., Rosen H., Kornek G. V., Sebesta C., Depisch D. Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer. BMJ. 1993 Mar 20;306(6880):752–755. doi: 10.1136/bmj.306.6880.752. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams N. S., Dixon M. F., Johnston D. Reappraisal of the 5 centimetre rule of distal excision for carcinoma of the rectum: a study of distal intramural spread and of patients' survival. Br J Surg. 1983 Mar;70(3):150–154. doi: 10.1002/bjs.1800700305. [DOI] [PubMed] [Google Scholar]
- Williams N. S. The rationale for preservation of the anal sphincter in patients with low rectal cancer. Br J Surg. 1984 Aug;71(8):575–581. doi: 10.1002/bjs.1800710802. [DOI] [PubMed] [Google Scholar]