Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
. 1998 Feb;77(4):552–555. doi: 10.1038/bjc.1998.89

Cytogenetic abnormalities in Langerhans cell histiocytosis.

D R Betts 1, K E Leibundgut 1, A Feldges 1, H J Plüss 1, F K Niggli 1
PMCID: PMC2149945  PMID: 9484810

Abstract

We present the cytogenetic investigations of five histiocytic tumour lesions from children. In four cases there was a confirmed diagnosis of Langerhans cell histiocytosis (LCH) and one case of histiocytosis that did not fulfil all the criteria for true LCH. All five cases showed cytogenetic abnormalities, including the first report of an abnormal clone in LCH. The clone showed a t(7;12)(q11.2;p13) translocation and was detected in only a small percentage of cells. This case and a further three also contained non-clonal abnormalities and an increase in chromosome breakage. The fifth case, the only one in which no acquired abnormalities were seen, had a constitutional paracentric inversion of chromosome 13q.

Full text

PDF
552

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Egeler R. M., Neglia J. P., Aricò M., Favara B. E., Heitger A., Nesbit M. E. Acute leukemia in association with Langerhans cell histiocytosis. Med Pediatr Oncol. 1994;23(2):81–85. doi: 10.1002/mpo.2950230204. [DOI] [PubMed] [Google Scholar]
  2. Egeler R. M., Neglia J. P., Puccetti D. M., Brennan C. A., Nesbit M. E. Association of Langerhans cell histiocytosis with malignant neoplasms. Cancer. 1993 Feb 1;71(3):865–873. doi: 10.1002/1097-0142(19930201)71:3<865::aid-cncr2820710334>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  3. Frost J. D., Wiersma S. R. Progressive Langerhans cell histiocytosis in an infant with Klinefelter syndrome successfully treated with allogeneic bone marrow transplantation. J Pediatr Hematol Oncol. 1996 Nov;18(4):396–400. doi: 10.1097/00043426-199611000-00013. [DOI] [PubMed] [Google Scholar]
  4. Gadner H., Heitger A., Grois N., Gatterer-Menz I., Ladisch S. Treatment strategy for disseminated Langerhans cell histiocytosis. DAL HX-83 Study Group. Med Pediatr Oncol. 1994;23(2):72–80. doi: 10.1002/mpo.2950230203. [DOI] [PubMed] [Google Scholar]
  5. Greenberger J. S., Crocker A. C., Vawter G., Jaffe N., Cassady J. R. Results of treatment of 127 patients with systemic histiocytosis. Medicine (Baltimore) 1981 Sep;60(5):311–338. doi: 10.1097/00005792-198109000-00001. [DOI] [PubMed] [Google Scholar]
  6. Kaneko Y., Maseki N., Sakurai M., Ido M., Tsunematsu Y., Mizutani S., Hattori T., Shimizu H., Eguchi H., Oka T. Clonal and non-clonal karyotypically abnormal cells in haemophagocytic lymphohistiocytosis. Br J Haematol. 1995 May;90(1):48–55. doi: 10.1111/j.1365-2141.1995.tb03379.x. [DOI] [PubMed] [Google Scholar]
  7. LICHTENSTEIN L. Histiocytosis X; integration of eosinophilic granuloma of bone, Letterer-Siwe disease, and Schüller-Christian disease as related manifestations of a single nosologic entity. AMA Arch Pathol. 1953 Jul;56(1):84–102. [PubMed] [Google Scholar]
  8. Ornvold K., Carstensen H., Larsen J. K., Christensen I. J., Ralfkiaer E. Flow cytometric DNA analysis of lesions from 18 children with langerhans cell histiocytosis (histiocytosis x). Am J Pathol. 1990 Jun;136(6):1301–1307. [PMC free article] [PubMed] [Google Scholar]
  9. Orye E., Benoit Y., Coppieters R., Jeannin P., Vercruysse C., Delaey J., Delbeke M. J. A case of retinoblastoma, associated with histiocytosis-X and mosaicism of a deleted D-group chromosome (13q14 leads to q31). Clin Genet. 1982 Jul;22(1):37–39. [PubMed] [Google Scholar]
  10. Rabkin M. S., Wittwer C. T., Kjeldsberg C. R., Piepkorn M. W. Flow-cytometric DNA content of histiocytosis X (Langerhans cell histiocytosis). Am J Pathol. 1988 May;131(2):283–289. [PMC free article] [PubMed] [Google Scholar]
  11. Vanni R., Marras S., Ravarino A., Faa G., Medda C. Chromosome changes in nonneoplastic tissue. Numerical and structural abnormalities in nasal polyps with atypical stromal cells. Cancer Genet Cytogenet. 1996 Jun;88(2):158–162. doi: 10.1016/0165-4608(95)00288-x. [DOI] [PubMed] [Google Scholar]
  12. Willis B., Ablin A., Weinberg V., Zoger S., Wara W. M., Matthay K. K. Disease course and late sequelae of Langerhans' cell histiocytosis: 25-year experience at the University of California, San Francisco. J Clin Oncol. 1996 Jul;14(7):2073–2082. doi: 10.1200/JCO.1996.14.7.2073. [DOI] [PubMed] [Google Scholar]
  13. Willman C. L., Busque L., Griffith B. B., Favara B. E., McClain K. L., Duncan M. H., Gilliland D. G. Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease. N Engl J Med. 1994 Jul 21;331(3):154–160. doi: 10.1056/NEJM199407213310303. [DOI] [PubMed] [Google Scholar]
  14. Willman C. L. Detection of clonal histiocytes in Langerhans cell histiocytosis: biology and clinical significance. Br J Cancer Suppl. 1994 Sep;23:S29–S33. [PMC free article] [PubMed] [Google Scholar]
  15. Wurster-Hill D. H., Brown F., Park J. P., Gibson S. H. Cytogenetic studies in Dupuytren contracture. Am J Hum Genet. 1988 Sep;43(3):285–292. [PMC free article] [PubMed] [Google Scholar]
  16. Yu R. C., Chu A. C. Lack of T-cell receptor gene rearrangements in cells involved in Langerhans cell histiocytosis. Cancer. 1995 Mar 1;75(5):1162–1166. doi: 10.1002/1097-0142(19950301)75:5<1162::aid-cncr2820750516>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  17. Yu R. C., Chu C., Buluwela L., Chu A. C. Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis. Lancet. 1994 Mar 26;343(8900):767–768. doi: 10.1016/s0140-6736(94)91842-2. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES