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. 1998 Mar;77(5):825–829. doi: 10.1038/bjc.1998.134

Childhood cancer and paternal employment in agriculture: the role of pesticides.

N T Fear 1, E Roman 1, G Reeves 1, B Pannett 1
PMCID: PMC2149972  PMID: 9514065

Abstract

Previous studies have suggested that the offspring of men potentially exposed to pesticides at work may be at increased risk of kidney cancer (Wilms' tumour), brain tumours, Ewing's bone sarcoma and acute leukaemia. This paper examines the association between potential occupational exposure of fathers to pesticides and offspring's death from cancer in a large national database. Records for 167703 childhood deaths occurring during 1959-63, 1970-78 and 1979-90 in England and Wales have been analysed. Among the offspring of men with potential occupational exposure to pesticides there were 5270 deaths, of which 449 were due to cancer. Associations were assessed using proportional mortality ratios (PMRs), with adjustment for age, year of death and paternal social class. Of the childhood cancers previously linked with potential paternal occupational exposure to pesticides, the only statistically significant excess was for kidney cancer (PMR=1.59, 95% CI=1.18-2.15, based on 42 deaths). Although these results offer some support for the suggestion that paternal occupational exposure to pesticides may be related to the subsequent development of kidney cancer in offspring, other explanations cannot be excluded. In the light of the findings presented here and elsewhere, further, more detailed, research into the nature of this relationship is warranted.

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Selected References

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  1. Beral V., Inskip H., Fraser P., Booth M., Coleman D., Rose G. Mortality of employees of the United Kingdom Atomic Energy Authority, 1946-1979. Br Med J (Clin Res Ed) 1985 Aug 17;291(6493):440–447. doi: 10.1136/bmj.291.6493.440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Birch J. M., Marsden H. B., Jones P. H., Pearson D., Blair V. Improvements in survival from childhood cancer: results of a population based survey over 30 years. Br Med J (Clin Res Ed) 1988 May 14;296(6633):1372–1376. doi: 10.1136/bmj.296.6633.1372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Buckley J. D., Buckley C. M., Ruccione K., Sather H. N., Waskerwitz M. J., Woods W. G., Robison L. L. Epidemiological characteristics of childhood acute lymphocytic leukemia. Analysis by immunophenotype. The Childrens Cancer Group. Leukemia. 1994 May;8(5):856–864. [PubMed] [Google Scholar]
  4. Bunin G. R., Kramer S., Marrero O., Meadows A. T. Gestational risk factors for Wilms' tumor: results of a case-control study. Cancer Res. 1987 Jun 1;47(11):2972–2977. [PubMed] [Google Scholar]
  5. Cordier S., Iglesias M. J., Le Goaster C., Guyot M. M., Mandereau L., Hemon D. Incidence and risk factors for childhood brain tumors in the Ile de France. Int J Cancer. 1994 Dec 15;59(6):776–782. doi: 10.1002/ijc.2910590612. [DOI] [PubMed] [Google Scholar]
  6. Davis D. L., Friedler G., Mattison D., Morris R. Male-mediated teratogenesis and other reproductive effects: biologic and epidemiologic findings and a plea for clinical research. Reprod Toxicol. 1992;6(4):289–292. doi: 10.1016/0890-6238(92)90190-5. [DOI] [PubMed] [Google Scholar]
  7. Draper G. J. General overview of studies of multigeneration carcinogenesis in man, particularly in relation to exposure to chemicals. IARC Sci Publ. 1989;(96):275–288. [PubMed] [Google Scholar]
  8. Gold E. B., Sever L. E. Childhood cancers associated with parental occupational exposures. Occup Med. 1994 Jul-Sep;9(3):495–539. [PubMed] [Google Scholar]
  9. Gold E., Gordis L., Tonascia J., Szklo M. Risk factors for brain tumors in children. Am J Epidemiol. 1979 Mar;109(3):309–319. doi: 10.1093/oxfordjournals.aje.a112684. [DOI] [PubMed] [Google Scholar]
  10. Hemminki K., Saloniemi I., Salonen T., Partanen T., Vainio H. Childhood cancer and parental occupation in Finland. J Epidemiol Community Health. 1981 Mar;35(1):11–15. doi: 10.1136/jech.35.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Holly E. A., Aston D. A., Ahn D. K., Kristiansen J. J. Ewing's bone sarcoma, paternal occupational exposure, and other factors. Am J Epidemiol. 1992 Jan 15;135(2):122–129. doi: 10.1093/oxfordjournals.aje.a116265. [DOI] [PubMed] [Google Scholar]
  12. Kristensen P., Andersen A., Irgens L. M., Bye A. S., Sundheim L. Cancer in offspring of parents engaged in agricultural activities in Norway: incidence and risk factors in the farm environment. Int J Cancer. 1996 Jan 3;65(1):39–50. doi: 10.1002/(SICI)1097-0215(19960103)65:1<39::AID-IJC8>3.0.CO;2-2. [DOI] [PubMed] [Google Scholar]
  13. Laval G., Tuyns A. J. Environmental factors in childhood leukaemia. Br J Ind Med. 1988 Dec;45(12):843–844. doi: 10.1136/oem.45.12.843. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Leiss J. K., Savitz D. A. Home pesticide use and childhood cancer: a case-control study. Am J Public Health. 1995 Feb;85(2):249–252. doi: 10.2105/ajph.85.2.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Lowengart R. A., Peters J. M., Cicioni C., Buckley J., Bernstein L., Preston-Martin S., Rappaport E. Childhood leukemia and parents' occupational and home exposures. J Natl Cancer Inst. 1987 Jul;79(1):39–46. [PubMed] [Google Scholar]
  16. Magnani C., Pastore G., Luzzatto L., Terracini B. Parental occupation and other environmental factors in the etiology of leukemias and non-Hodgkin's lymphomas in childhood: a case-control study. Tumori. 1990 Oct 31;76(5):413–419. doi: 10.1177/030089169007600501. [DOI] [PubMed] [Google Scholar]
  17. Meinert R., Kaatsch P., Kaletsch U., Krummenauer F., Miesner A., Michaelis J. Childhood leukaemia and exposure to pesticides: results of a case-control study in northern Germany. Eur J Cancer. 1996 Oct;32A(11):1943–1948. doi: 10.1016/0959-8049(96)00231-6. [DOI] [PubMed] [Google Scholar]
  18. Mulder Y. M., Drijver M., Kreis I. A. Case-control study on the association between a cluster of childhood haematopoietic malignancies and local environmental factors in Aalsmeer, The Netherlands. J Epidemiol Community Health. 1994 Apr;48(2):161–165. doi: 10.1136/jech.48.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Olshan A. F., Breslow N. E., Falletta J. M., Grufferman S., Pendergrass T., Robison L. L., Waskerwitz M., Woods W. G., Vietti T. J., Hammond G. D. Risk factors for Wilms tumor. Report from the National Wilms Tumor Study. Cancer. 1993 Aug 1;72(3):938–944. doi: 10.1002/1097-0142(19930801)72:3<938::aid-cncr2820720345>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  20. Schwartzbaum J. A., George S. L., Pratt C. B., Davis B. An exploratory study of environmental and medical factors potentially related to childhood cancer. Med Pediatr Oncol. 1991;19(2):115–121. doi: 10.1002/mpo.2950190209. [DOI] [PubMed] [Google Scholar]
  21. Sharpe C. R., Franco E. L. Etiology of Wilms' tumor. Epidemiol Rev. 1995;17(2):415–432. doi: 10.1093/oxfordjournals.epirev.a036201. [DOI] [PubMed] [Google Scholar]
  22. Sharpe C. R., Franco E. L., de Camargo B., Lopes L. F., Barreto J. H., Johnsson R. R., Mauad M. A. Parental exposures to pesticides and risk of Wilms' tumor in Brazil. Am J Epidemiol. 1995 Feb 1;141(3):210–217. doi: 10.1093/oxfordjournals.aje.a117422. [DOI] [PubMed] [Google Scholar]
  23. Stiller C. A., Allen M. B., Eatock E. M. Childhood cancer in Britain: the National Registry of Childhood Tumours and incidence rates 1978-1987. Eur J Cancer. 1995 Nov;31A(12):2028–2034. doi: 10.1016/0959-8049(95)00428-9. [DOI] [PubMed] [Google Scholar]
  24. Stiller C. A., Bunch K. J. Trends in survival for childhood cancer in Britain diagnosed 1971-85. Br J Cancer. 1990 Nov;62(5):806–815. doi: 10.1038/bjc.1990.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Stiller C. A., McKinney P. A., Bunch K. J., Bailey C. C., Lewis I. J. Childhood cancer and ethnic group in Britain: a United Kingdom children's Cancer Study Group (UKCCSG) study. Br J Cancer. 1991 Sep;64(3):543–548. doi: 10.1038/bjc.1991.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Stiller C. A. Population based survival rates for childhood cancer in Britain, 1980-91. BMJ. 1994 Dec 17;309(6969):1612–1616. doi: 10.1136/bmj.309.6969.1612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Wilkins J. R., 3rd, Koutras R. A. Paternal occupation and brain cancer in offspring: a mortality-based case-control study. Am J Ind Med. 1988;14(3):299–318. doi: 10.1002/ajim.4700140308. [DOI] [PubMed] [Google Scholar]
  28. Wilkins J. R., 3rd, Sinks T. H., Jr Occupational exposures among fathers of children with Wilms' tumor. J Occup Med. 1984 Jun;26(6):427–435. doi: 10.1097/00043764-198406000-00015. [DOI] [PubMed] [Google Scholar]
  29. Wilkins J. R., 3rd, Sinks T. H., Jr Paternal occupation and Wilms' tumour in offspring. J Epidemiol Community Health. 1984 Mar;38(1):7–11. doi: 10.1136/jech.38.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Wilkins R. J. Genomic imprinting and carcinogenesis. Lancet. 1988 Feb 13;1(8581):329–331. doi: 10.1016/s0140-6736(88)91121-x. [DOI] [PubMed] [Google Scholar]
  31. Zack M., Cannon S., Loyd D., Heath C. W., Jr, Falletta J. M., Jones B., Housworth J., Crowley S. Cancer in children of parents exposed to hydrocarbon-related industries and occupations. Am J Epidemiol. 1980 Mar;111(3):329–336. doi: 10.1093/oxfordjournals.aje.a112904. [DOI] [PubMed] [Google Scholar]

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